A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2.

During embryonic development, Wnt signaling influences both proliferation and sensory formation in the cochlea. How this dual nature of Wnt signaling is coordinated is unknown. In this study, we define a novel role for a Wnt-regulated gene, Mybl2, which was already known to be important for proliferation, in determining the size and patterning of the sensory epithelium in the murine cochlea.

Fertility and pregnancy outcomes in women with Turner syndrome: A single centre experience.

Objective: Many women with Turner syndrome (TS) will consider fertility options and pregnancy. We wished to examine the fertility and pregnancy outcomes in women with TS undergoing oocyte donation (OD) treatment or spontaneous pregnancy in a large single-centre cohort. General population reference data or data from those with idiopathic premature ovarian insufficiency were used as comparators.

SRC-1 controls growth cone polarity and protrusion with the UNC-6/Netrin receptor UNC-5 in Caenorhabditis elegans.

The Polarity/Protusion model of UNC-6/Netrin function in axon repulsion does not rely on a gradient of UNC-6/Netrin. Instead, the UNC-5 receptor polarizes the VD growth cone such that filopodial protrusions are biased to the dorsal leading edge. UNC-5 then inhibits growth cone protrusion ventrally based upon this polarity, resulting in dorsally-biased protrusion and dorsal migration away from UNC-6/Netrin.

An Algorithm to Estimate the Power Spectral Density From Allan Deviation.

Complex architectures for wireless communications, digital electronics, and space-based navigation interlink several oscillator-based devices such as clocks, transponders, and synthesizers. Estimators characterizing their stability are critical for addressing the impact of random fluctuations (noise) on the overall system performance. Manufacturers typically specify this as an Allan/Hadamard Variance (AVAR/HVAR) profile in the time domain.

Sensory progenitors influence patterning of the mammalian auditory sensory epithelium.

Unlabelled: During embryonic development Wnt signaling has been shown to influence proliferation and sensory formation in the cochlea. How the dual nature of Wnt signaling is coordinated is unknown. In this study, we define a novel role for a Wnt regulated gene, which was already known to be important for proliferation, in influencing patterning and determining the size of the sensory epithelium in the murine cochlea.