[The induction of an immune response to influenza virus antigens by anti-idiotypic antibodies].

The present investigation indicate that homologous polyclonal anti-idiotypic antibodies induce both humoral and cell-mediated immune response. Experiments on the exhaustion of immune sera with vaccine have revealed that anti-idiotypic antibodies induce not only specific antibodies to influenza virus antigens, but also antibodies to other epitopes of the globulin molecule of the anti-idiotype. Anti-idiotypic antibodies, when reintroduced into animals, induce the production of anti-influenza antibodies of the anamnestic type, but do not induce the formation of antihemagglutinins.

[Anti-influenzal antibodies inducing an immune response to the influenza virus].

The injection of anti-influenza antibodies into rabbits induces a specific immune response, including the production of anti-idiotypic antibodies and then the production of immune complexes and anti-influenza antibodies. The injection of antibodies induces the development of immunological memory; as a result, the animals are primed to respond to the injection of influenza vaccine.

[The antigenic characteristics of influenza A viral strains circulating synchronously in 2 separated areas (the CzSFR--Saint Petersburg)].

A comparative study of the antigenic characteristics of influenza A (H1N1) and A (H3N2) virus strains isolated during the same epidemic season, 1989-1990, in St. Petersburg and CzSFR was carried out by routine serological methods and by cross-challenge of immunized mice. Antigenic differences were found only among serosubtype A (H1N1) strains isolated in different areas.

[The anti-idiotypic response to the experimental administration of the inactivated or live influenza virus].

The injection of inactivated and live influenza virus into rabbits induces the formation of anti-idiotypic antibodies, appearing after anti-influenza hemagglutinins, in the blood. The presence of immune complexes antibody--anti-idiotypic antibody in the blood of the animals has been established. The booster immunization of the animals with influenza virus antigens produces a rise in the levels of both idiotypic and anti-idiotypic antibodies.