Publications by authors named "E A Beuling"

The forkhead transcription factor FOXP1 is generally regarded as an oncogene in activated B cell-like diffuse large B-cell lymphoma. Previous studies have suggested that a small isoform of FOXP1 rather than full-length FOXP1, may possess this oncogenic activity. Corroborating those studies, we herein show that activated B cell-like diffuse large B-cell lymphoma cell lines and primary activated B cell-like diffuse large B-cell lymphoma cells predominantly express a small FOXP1 isoform, and that the 5'-end of the gene is a common insertion site in murine lymphomas in leukemia virus- and transposon-mediated insertional mutagenesis screens.

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IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia. Recent studies suggest that IKZF1 is also involved in myeloid differentiation. To investigate whether IKZF1 deletions also play a role in pediatric acute myeloid leukemia, we screened a panel of pediatric acute myeloid leukemia samples for deletions of the IKZF1 locus using multiplex ligation-dependent probe amplification and for mutations using direct sequencing.

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Controlled renewal of the epithelium with precise cell distribution and gene expression patterns is essential for colonic function. GATA6 is expressed in the colonic epithelium, but its function in the colon is currently unknown. To define GATA6 function in the colon, we conditionally deleted Gata6 throughout the epithelium of small and large intestines of adult mice.

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Background & Aims: GATA transcription factors regulate proliferation, differentiation, and gene expression in multiple organs. GATA4 is expressed in the proximal 85% of the small intestine and regulates the jejunal-ileal gradient in absorptive enterocyte gene expression. GATA6 is co-expressed with GATA4 but also is expressed in the ileum; its function in the mature small intestine is unknown.

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Article Synopsis
  • GATA4 is a transcription factor that normally restricts bile acid transporter ASBT expression to the distal ileum, and its reduction in the small intestine can stimulate bile acid absorption in the proximal region.
  • Experiments on mice with altered GATA4 activity showed increased ASBT expression and improved bile acid absorption in the small intestine after a surgical resection.
  • The findings suggest that lowering GATA4 activity could effectively correct bile acid malabsorption following ileocaecal resection without significantly disrupting overall bile acid homeostasis.
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