Evaluation of modified methods for determining skin irritation.

The premarket testing of household cleaning products for dermal irritancy is best achieved via human testing. Animal dermal irritation testing is generally limited to screening for possible dermal hazard of totally new or unique products or ingredients prior to human testing or to meeting regulatory requirements of government bodies. Alternatives to animal tests are being sought; however, until such time that these alternatives are identified, validated, and accepted by government bodies, the judicious use of animal testing remains a necessity.

Pseudotumour of the corpus callosum due to subarachnoid haemorrhage from pericallosal aneurysm.

Two patients were scanned 2-5 weeks following onset of subarachnoid haemorrhage. A similar CT appearance was seen in each case. A ring enhancing mass lesion was present within the corpus callosum, suggesting an underlying tumour.

Radionuclide imaging of the neck in rheumatoid arthritis.

Blind marking was used to assess radionuclide neck images obtained with technetium-99m methylene diphosphonate in 28 patients with rheumatoid arthritis and 12 with cervical degenerative joint disease (spondylosis). Eleven out of the 16 rheumatoid arthritis patients who had neck pain when imaged showed enhanced uptake in the region of the atlantoaxial and temporomandibular joints. In contrast, no patient with cervical spondylosis and only one rheumatoid arthritis patient without neck pain had high uptake in either joint.