Publications by authors named "E A Arnaud"
Objective: Craniosynostoses are an underrecognized cause of intracranial hypertension (ICH), especially when associated with congenital syndromes. Alagille syndrome (ALGS) is a multisystem disorder with typical facial features and hepatobiliary, cardiac, vascular, skeletal, and ocular manifestations. The occurrence of craniosynostosis in ALGS is rare and can be associated with chronic ICH, requiring craniofacial surgery to increase the intracranial volume.
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- The study investigates the significance of lymph node yield (LNY) in head and neck squamous cell carcinoma (HNSCC) and how various factors influence it, focusing on surgeons, pathologists, and patient characteristics.
- Findings reveal that surgeon experience, tumor characteristics, and patient demographics (like age and BMI) affect LNY, with a specific LNY threshold linked to better survival outcomes in the oral cavity.
- The authors conclude that while certain factors influence LNY and its correlation with survival, more research is needed to evaluate its role as a standard quality measure in HNSCC treatment.
Article Synopsis
- Fronto-orbital advancement (FOA) is the primary treatment for craniosynostosis and has been performed using gradual distraction techniques in Asia, but not widely adopted in the West due to potential scalp tension differences among patients.
- A study compared skin tension measurements in 12 European and 16 Asian patients undergoing cranioplasty, revealing that European patients exhibited higher tension levels, particularly on the left and right sides.
- The findings indicate that scalp tension varies by race, which should be taken into account when determining the best treatment approach for craniosynostosis.
Purpose: The etiopathogenesis of coronal nonsyndromic craniosynostosis (cNCS), a congenital condition defined by premature fusion of 1 or both coronal sutures, remains largely unknown.
Methods: We conducted the largest genome-wide association study of cNCS followed by replication, fine mapping, and functional validation of the most significant region using zebrafish animal model.
Results: Genome-wide association study identified 6 independent genome-wide-significant risk alleles, 4 on chromosome 7q21.
Background: Fronto-facial monobloc advancement with internal distraction (FFMBA) is a central procedure in the management of FGFR-related craniosynostoses. Children undergoing FFMBA may present with resorption of the frontal bony flap in the months or years following surgery. Here, we aimed at identifying the clinical factors associated with resorption and its extent in patients with Crouzon and Pfeiffer syndromes.
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