Role of Ciliary Neurotrophic Factor in Angiotensin II-Induced Hypertension.

Background: Ciliary neurotrophic factor (CNTF), mainly known for its neuroprotective properties, belongs to the IL-6 (interleukin-6) cytokine family. In contrast to IL-6, the effects of CNTF on the vasculature have not been explored. Here, we examined the role of CNTF in AngII (angiotensin II)-induced hypertension.

Validation and Cutoff Value of the Brazilian Version of the Evaluation of the Ability to Sing Easily-EASE.

Objective: To validate the Evaluation of the Ability to Sing Easily (EASE) scale for Brazilian Portuguese.

Methods: A total of 391 singers participated in the study-192 females and 198 males, with a mean age of 33 years. Validation was performed according to the criteria recommended by the COnsensus-based Standards for the selection of health Measurement INstruments, evaluating the following domains, properties, and measurement: reliability (reliability and internal consistency), construct validity (transcultural validity and structural validity), and criterion validity (concurrent criterion validity).

Plantago boissieri: Phytochemical Assessment, Antioxidant, Anti-inflammatory and Wound Healing Potential.

Plantago is a large genus under family Plantaginaceae. Several Plantago species were noted for potent antioxidant, anti-inflammatory and wound healing activities. The current research investigated the potential bioactivities as well as the metabolic content of Plantago boisserei extract.

Multi-omics data integration and analysis pipeline for precision medicine: Systematic review.

Precision medicine has gained considerable popularity since the "one-size-fits-all" approach did not seem very effective or reflective of the complexity of the human body. Subsequently, since single-omics does not reflect the complexity of the human body's inner workings, it did not result in the expected advancement in the medical field. Therefore, the multi-omics approach has emerged.