The RdRp genotyping of SARS-CoV-2 isolated from patients with different clinical spectrum of COVID-19.

Background: The evolution of SARS-CoV-2 has been observed from the very beginning of the fight against COVID-19, some mutations are indicators of potentially dangerous variants of the virus. However, there is no clear association between the genetic variants of SARS-CoV-2 and the severity of COVID-19. We aimed to analyze the genetic variability of RdRp in correlation with different courses of COVID-19.

Comparative study of virulence potential, phylogenetic origin, CRISPR- regions and drug resistance of isolates from urine and other clinical materials.

Introduction: Urinary tract infections (UTI), among which the main etiological factor is uropathogenic (UPEC, ), remain an important issue for clinicians. The aim of the study was to demonstrate clear differences in the pathogenic properties of urine-derived compared to other extraintestinal clinical isolates (derived from: blood, lower respiratory tracts, sputum, reproductive tract, body fluids, perianal pus, other pus, wound, postoperative wound and other sources).

Methods: The collection of 784 isolates was collected from various materials of hospitalized patients.

Awake endotracheal intubation using a hyperangulated video laryngoscope with a Total Control Introducer in a patient with a history of difficult intubation.

We report the first use of a fully articulating introducer called the Total Control Introducer (TCI) in combination with a hyperangulated video laryngoscope (VL) to perform an awake intubation in a patient with a history of difficult intubation. After appropriate airway topicalisation, a VL with a hyperangulated blade was inserted to visualise the glottis. A TCI articulating introducer was then used to dynamically navigate through the oropharynx into the trachea.

Longitudinal associations between physical activity and five risk factors of metabolic syndrome in middle-aged adults in Germany.

Background: We examined the longitudinal association between (change in) physical activity (PA) with new onset of five risk factors of metabolic syndrome among 657 middle-aged adults (mean age 44.1 (standard deviation (SD) 8.6) years) who were free of the respective outcome at baseline, in a longitudinal cohort study spanning over 29 years.

Characterization of the Dahl salt-sensitive rat as a rodent model of inherited, widespread, persistent pain.

Animal models are essential for studying the pathophysiology of chronic pain disorders and as screening tools for new therapies. However, most models available do not reproduce key characteristics of clinical persistent pain. This has limited their ability to accurately predict which new medicines will be clinically effective.

Association Between Sense of Coherence and Health Outcomes at 10 and 20 Years Follow-Up: A Population-Based Longitudinal Study in Germany.

The sense of coherence (SOC) is reported to influence health, but health may also have an impact on SOC. The objective of this study was to examine the longitudinal associations between SOC and selected self-reported and physician-assessed health outcomes over a period of 10 and 20 years and to determine the predominant direction of the associations. We conducted a population-based, longitudinal study, involving 392 participants (188 females and 204 males; mean age 43.

Elites Do Not Deplete - No Effect of Prior Mental Exertion on Subsequent Shooting Performance in Elite Shooters.

In order to perform at the highest level, elite shooters have to remain focused during the whole course of a tournament, which regularly lasts multiple hours. Investing self-control over extended time periods is often associated with lower levels of perceived self-control strength (i.e.

Infection Acts Synergistically with a High-Fat Diet in the Development of a Proinflammatory and Potentially Proatherogenic Endothelial Cell Environment in an Experimental Model.

Classic atherosclerosis risk factors do not explain all cases of chronic heart disease. There is significant evidence that gut microbiota may influence the development of atherosclerosis. The widespread prevalence of chronic (, ) infections suggests that can be the source of components that stimulate local and systemic inflammatory responses.

Testing the Effects of a Preceding Self-Control Task on Decision-Making in Soccer Refereeing.

The present study tested the assumption that the momentary level of self-control strength affects the accuracy rates in a sports-related judgment and decision-making task. A total of = 27 participants rated the veracity of 28 video-taped statements of soccer players who were interviewed by a non-visible referee after a critical game-related situation. In half of the videos, the players were lying, and in the other half, they were telling the truth.

Intra- and inter-rater reliability of joint range of motion tests using tape measure, digital inclinometer and inertial motion capturing.

Background: In clinical practice range of motion (RoM) is usually assessed with low-cost devices such as a tape measure (TM) or a digital inclinometer (DI). However, the intra- and inter-rater reliability of typical RoM tests differ, which impairs the evaluation of therapy progress. More objective and reliable kinematic data can be obtained with the inertial motion capture system (IMC) by Xsens.

Gender is not simply a matter of black and white, or is it?

Based on research in physical anthropology, we argue that brightness marks the abstract category of gender, with light colours marking the female gender and dark colours marking the male gender. In a set of three experiments, we examine this hypothesis, first in a speeded gender classification experiment with male and female names presented in black and white. As expected, male names in black and female names in white are classified faster than the reverse gender-colour combinations.

Biomechanical parameters in lower limbs during natural walking and Nordic walking at different speeds.

Purpose: Nordic Walking (NW) is a sport that has a number of benefits as a rehabilitation method. It is performed with specially designed poles and has been often recommended as a physical activity that helps reduce the load to limbs. However, some studies have suggested that these findings might be erroneous.

Index of mechanical work in gait of children with cerebral palsy.

The pathological gait of children with cerebral palsy involves higher mechanical work, which limits their ability to function properly in society. Mechanical work is directly related to walking speed and, although a number of studies have been carried out in this field, few of them analysed the effect of the speed. The study aimed to develop standards for mechanical work during gait of children with cerebral palsy depending on the walking speed.

Ancient origins and evolutionary conservation of intracellular and neural signaling pathways engaged by the leptin receptor.

In mammals, leptin acts on leptin receptor (LepR) -expressing neurons in the brain to suppress food intake and stimulate whole-body metabolism. A similar action of leptin on food intake has been reported in the frog Xenopus laevis and in several bony fishes. However, the intracellular signaling and neural pathways by which leptin regulates energy balance have not been investigated outside of mammals.

Grasping with the eyes: the role of elongation in visual recognition of manipulable objects.

Processing within the dorsal visual stream subserves object-directed action, whereas visual object recognition is mediated by the ventral visual stream. Recent findings suggest that the computations performed by the dorsal stream can nevertheless influence object recognition. Little is known, however, about the type of dorsal stream information that is available to assist in object recognition.

Integral method (IM) as a quantitative and objective method to supplement the GMFCS classification of gait in children with cerebral palsy (CP).

Gait analysis is an objective tool for the clinical assessment of locomotor activity in children with cerebral palsy (CP). Correct diagnosis and properly planned rehabilitation are necessary for enhanced motor functions in persons suffering from cerebral palsy. Orthoses, orthopedic operations, medications and physiotherapy are the most common treatments.

Magnetic resonance imaging (MRI) for assessment of differences in geometrical parameters in muscles stabilizing vertebral column in young and older persons. Case study.

Today non-traumatic low back pain (LBP) is a social disease being attributed to weakening the function of abdominal and back muscles. Condition of deep muscles, inaccessible to non-invasive examinations, can be assessed by means of magnetic resonance imaging (MRI). The method allows for the assessment of cross-sections, muscle girths, as well as their intensity (brightness).

Foot kinematics in gait of children with cerebral palsy (CP).

Cerebral palsy (CP) is a developmental disorder of motor, psychological and emotional functions. Its most typical symptom is a walking disorder. The aim of this study was to analyze children's walking abilities based on basic kinematic parameters.

Influence of mechanical hippotherapy on skin temperature responses in lower limbs in children with cerebral palsy.

Therapeutic horse riding is often employed for disabled children. The aim of the present paper was to determine the influence of exercise in a mechanical saddle, imitating horse's walk, on the skin temperature responses in lower limbs in children with cerebral palsy. Sixteen children, aged 14-16, were enrolled into the study.

Gait characteristics following Achilles tendon elongation: the foot rocker perspective.

The action of three functional rockers, namely the heel, ankle and forefoot rocker, assist the progression of the leg over the supporting foot. The purpose of this case series was to analyze the occurrence of foot rockers during gait in three children with cerebral palsy (CP) who had undergone the tendo-Achilles lengthening (TAL), procedure followed by a clinic- or home-based intervention and in one child with CP without history of surgery. Self-selected gait was video-recorded in a laboratory during six testing sessions at half-year intervals rendering a 3 year period of observation.

Short-term clinical experience with hip resurfacing arthroplasty.

Background: This paper discusses the authors' experience with hip resurfacing arthroplasty. Although introduced many years ago, the method did not gain wide popularity because of poor long-term outcomes. At present, owing to the introduction of metal-on-metal bearings and hybrid fixation techniques, short- and mid-term results are very good and encourage wider use of this technique, especially in the younger and more active patients whose results with standard total hip replacements would be unsatisfactory.

[Heart rate variability in patients with diffuse toxic goiter].

Functional state of the vegetative nervous system of 18 patients with first time diagnosed moderate thyrotoxicosis has been analyzed. Vegetative tonus, vegetative reactivity and vegetative activity during daily activity was assessed based on heart rate variability.