DEVELOPMENT OF NEW APPROACHES TO THE TREATMENT OF HEMANGIOMAS IN EXPERIMENT.

The aim of the study was to determine the endogenous factors regulating angiogenesis and develop new approaches to the treatment of uncontrolled growth of capillaries. The effect of a cell proliferation inhibiting thermostable protein complex (TPC), isolated from adult chicken liver, on an experimental model of Hemangioma (adolescent chicken comb) was studied. It has been proved that thermostable proteins isolated from the liver of adult chicken have the ability to inhibit the growth of adolescent bird comb.

COMPARATIVE STUDY OF GROWTH INHIBITORY PROTEIN COMPLEX DERIVED FROM DIFFERENT FORMS OF CHILDREN HEMANGIOMA.

The comparative analysis of the thermostable protein complexes obtained from the capillary and the cavernous hemangioma was carried out. It is shown that the active component (with low molecular weight 12-14 kD) is in minor content in the complexes obtained from capillary, as well as from the cavernous hemangioma. The effect of protein complexes from cavernous hemangiomas on proliferation of the brain and pancreatic cells in growing rats was studied.

Influence of halothane narcosis on a change of the number of GABA-positive cells in the hippocampus of adult rats with the midasolam premedication.

The most difficult questions in pediatric anesthesiology still remain relevant at surgeries to correct congenital maxilla-facial pathologies, accompanied by severe respiratory distress, speech and auditory sensation. For a long time the anesthetics were widely used among the neonatal and young children with extreme care due to their indicated suppressive effects on the immature organ systems. According to this fact, the choice of anesthesia is a matter of extremely importance.

The positive effects of Midazolam on functional activity of white rat brain cells in conditions of halothane anesthesia.

For the elimination of postoperative complications, which are evident in infants with congenital palatine and upper lip cleft after halothane anesthesia during standard premedication (Atropine, Dimedrol) the usage of agents of benzodiazepine group with anti-hypoxic effects is advised. The latter may modulate the blocked ion channels by neuromediators, which are activated by GABA and GABA receptor function. The neuro-protective ability of halothane is demonstrated.

[The comparative effectiveness of using basic preparations in the combined therapy of rheumatoid arthritis].

Comparison of the time-course of changes in the clinico-laboratory, x-ray and immunological findings in RA patients under the influence of the treatment with azathioprine (50 patients) sulfasalazine (42 patients) and their combination (48 patients) has demonstrated that the best effect (64.6%) may be provided by the use of combined therapy. Azathioprine and sulfasalazine should be administered in combination to patients with seropositive RA, systemic disease manifestations and a high laboratory activity as well as to patients with hormonal dependence.

[The efficacy of taktivin in patients with viral myocarditis and dilated cardiomyopathy].

The aim of the present research was to study the efficacy of the immunomodulating agent T-activin in patients with viral myocarditis and dilated cardiomyopathy (DCMP). The data obtained indicate that under the influence of the general therapy with T-activin cellular immunity manifested positive changes and the patients with viral myocarditis and DCMP felt better.

[Immunological characteristics of viral myocarditis].

A study of cellular and humoral immunity was conducted in patients with viral myocarditis. Quantitative and functional deficiency of T-suppressors and an increase in the number of cytotoxic lymphocytes were revealed in most patients. Disorder in the T-cellular link of immunity correlated with a clinical course of the disease and was found more frequently in patients with a grave course of myocarditis.

[Immunoregulatory lymphocyte subpopulations in patients with dilated and hypertrophic cardiomyopathies].

Forty patients with dilatation cardiomyopathy (DCM) and 30 patients with hypertrophic cardiomyopathy (HCM) were examined immunologically. Immunoregulatory lymphocytes (T1B) and their subpopulations (T helpers, T suppressors, natural killers--NK) were studied quantitatively and functionally. The patients with DCM showed inhibition of the number of T suppressors in part of the cases, attended by a decrease in non-specific (spontaneous) and mitogenin-induced suppressor activity, the lowering of the amount and activity of NK in the overwhelming majority of the cases.

[Characteristics of immunoregulatory lymphocyte subpopulations in patients with congestive cardiomyopathy and nonrheumatic myocarditis studied by monoclonal antibodies].

Forty patients and 14 donors were examined. Twenty-two patients were diagnosed to have congestive cardiomyopathy (CCM), and 18 to have non-rheumatic myocarditis. The total number of T and B lymphocytes and lymphocyte subpopulations were measured by the method of surface markers (T mu and T gamma) and concurrently with the aid of monoclonal antibodies (OKT 3, OKT 4, OKT 8).