Publications by authors named "Dyoi-E Low"
Article Synopsis
- The study investigates the prevalence of the HLA-B*58:01 allele, which is linked to severe skin reactions from allopurinol, among gout patients in Malaysia's multiethnic population.
- A total of 547 patients from Malay, Chinese, and Indian backgrounds were tested, revealing an overall allele prevalence of 16.8%, with the highest at 21.8% in Chinese patients.
- Notably, despite having the HLA-B*58:01 allele, none of the patients who used allopurinol developed severe cutaneous reactions, indicating the need for a better predictive model for these reactions.
Objective: To describe the clinical characteristics, management and quality of life of psoriasis patients with and without coexistent lupus erythematosus (LE).
Methods: This retrospective cross-sectional study uses data from the Malaysian Psoriasis Registry (MPR) from January 2007 to December 2018.
Results: Of 21 735 psoriasis patients, 34 (0.
Article Synopsis
- HLA-B*58:01 is strongly associated with allopurinol-induced severe cutaneous adverse reactions (AIS) in a multiethnic Malaysian population, with high prevalence in Chinese and Malay ethnic groups.
- A case-control study of 55 AIS patients revealed that 89.1% tested positive for HLA-B*58:01, significantly higher than the 14.3% in allopurinol-tolerant controls, indicating a strong risk factor for these adverse reactions.
- Specifically, the odds ratios for different clinical phenotypes show a particularly high risk in Chinese patients with AIS-SJS/TEN (100% HLA-B*58:01 positive) and notable strong associations in Malay patients as well
Background: Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disorder of follicular occlusion, resulting in abscesses with tunnel formation and severe scarring. Our objectives were to identify the clinical patterns and the prevalence of metabolic syndrome (MetS) among our HS patients and to determine the role of ultrasonography in the clinical assessment of HS.
Methods: This was a cross-sectional study carried out from September 2016 to August 2017 at three tertiary hospitals in Northern Peninsular Malaysia.