PI3 kinase inhibitor PI828 uncouples aminergic GPCRs and Ca mobilization irrespectively of its primary target.

The phosphoinositide 3-kinase (PI3K) is involved in regulation of multiple intracellular processes. Although the inhibitory analysis is generally employed for validating a physiological role of PI3K, increasing body of evidence suggests that PI3K inhibitors can exhibit PI3K-unrelated activity as well. Here we studied Ca signaling initiated by aminergic agonists in a variety of different cells and analyzed effects of the PI3K inhibitor PI828 on cell responsiveness.

Playgrounds in City of Pushchino with Different Types of Coating as Reservoir of Antibiotic-Resistant Strains of Pseudomonas spp.

In this study, we investigated antibiotic-resistant microorganisms isolated by the direct plating method from 6 playgrounds in the city of Pushchino, Moscow Region, with different types of coating: sand, soil with sand, grass and a modern playground coating made of pressed rubber crumb. According to the results of the study, sand is the cleanest type of coating, both in terms of the total count of cultivated microorganisms (8 × 10/g of substrate) and in terms of the content of resistant strains. The most contaminated both in terms of the total count of cultivated microorganisms (1.

[Features of certification for medical prophylactic and research institutions].

Based on experience of certification in N.N. Blokhin Russian Oncologic Research Center with RAMSc, the authors presented recommendation on certification of medical prophylactic and research institutions where the staffers treating oncologic patients and/ or conducting research work in contact with carcinogens.

[General and oncologic mortality in cohort of television workers].

Study covered general and oncologic mortality in TV workers exposed to low levels of nonionizing radiation. Some workers' groups selected by occupation and length of service demonstrate reliably lower mortality with overall causes, cardiovascular diseases and malignancies, but increased mortality risk with malignancies of some locations.

[Cancerogenic substances list disclosure (pasportization) in occupationally hazardous industries in the system of occupational monitoring].

The authors suggested criteria to systematize materials of conditioning for industries having carcinogenic jeopardy and to select industries with the highest carcinogenic jeopardy for the workers and general population.

[General and oncologic morbidity in Moscow municipal transport drivers].

A case study was undertaken to examine general and cancer mortality rates and cancer morbidity among municipal transport drivers in Moscow. The mortality and cancer morbidity in 1969 to 1988 were followed up among 2528 men and 212 women. In this period, male mortality rates due to malignant neoplasms, cardiovascular diseases and all causes taken together were statistically lower than the expected rates.

[Clinical and epidemiologic evaluation of carcinogenic pollution in the wood-processing industry].

Hygienic, clinical, epidemiologic studies in primary woodworking and chipboard production workers showed that exposure to occupational hazards (wooden dust, formaldehyde and other chemicals of wooden origin) results in frequent allergy and irritation of upper respiratory tract and skin. High oncologic risk among woodworking production employees assigns the industry to a group with oncologic jeopardy. MAC for wooden dust should be corrected taking into account the chemicals (phenol, formaldehyde, furans et al.