Adipocyte Glucocorticoid Receptor Inhibits Immune Regulatory Genes to Maintain Immune Cell Homeostasis in Adipose Tissue.

Glucocorticoids acting via the glucocorticoid receptors (GR) are key regulators of metabolism and the stress response. However, uncontrolled or excessive GR signaling adversely affects adipose tissue, including endocrine, immune, and metabolic functions. Inflammation of the adipose tissue promotes systemic metabolic dysfunction; however, the molecular mechanisms underlying the role of adipocyte GR in regulating genes associated with adipose tissue inflammation are poorly understood.

Emissive Substoichiometric Covalent Organic Frameworks for Water Sensing and Harvesting.

Emissive covalent organic frameworks (COFs) have recently emerged as next-generation porous materials with attractive properties such as tunable topology, porosity, and inherent photoluminescence. Among the different types of COFs, substoichiometric frameworks (so-called Type III COFs) are especially attractive due to the possibility of not only generating unusual topology and complex pore architectures but also facilitating the introduction of well-defined functional groups at precise locations for desired functions. Herein, the first example of a highly emissive (PLQY 6.

Crystal Structure and Optical Properties of a Chiral Mixed Thiolate/Stibine-Protected Au Cluster.

We report the first example of a chiral mixed thiolate/stibine-protected gold cluster, formulated as Au(S-Adm)(SbPh)Br (where S-Adm = 1-adamantanethiolate). Single crystal X-ray crystallography reveals the origin of chirality in the cluster to be the introduction of the rotating arrangement of Au(S-Adm) and Au(S-Adm) staple motifs on an achiral Au core and the subsequent capping of the remaining gold atoms by SbPh and Br ligands. Interestingly, the structure and properties of this new Au cluster are found to be different from other reported achiral Au clusters and the only other stibine-protected [Au(SbPh)Cl] cluster.