Charge-Transfer Spectroscopy of Ag(Benzene) and Ag(Toluene).

Gas-phase ion-molecule complexes of silver cation with benzene or toluene are produced via laser vaporization in a pulsed supersonic expansion. These ions are mass-selected and photodissociated with tunable UV-visible lasers. In both cases, photodissociation produces the organic cation as the only fragment via a metal-to-ligand charge-transfer process.

Communication: Electronic transition of the l-C cation at 417 nm.

A new electronic transition is reported for the linear C cation with an origin at 416.8 nm. This spectrum can be compared to the matrix isolation spectra at lower energies reported previously by Fulara et al.

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates.

Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized. Here we describe the discovery of a series of benzoxaborole compounds with nanomolar activity against extra- and intracellular stages of T.

The Role of Tunneling in the Spectra of H and D up to 7300 cm.

The spectra for H and D are extended to cover the region between 4830 and 7300 cm. These spectra are obtained using mass-selected photodissociation spectroscopy. To understand the nature of the states that are accessed by the transitions in this and prior studies, we develop a four-dimensional model Hamiltonian.

Spontaneous dormancy protects during extended drug exposure.

The ability of the Chagas disease agent to resist extended in vivo exposure to highly effective trypanocidal compounds prompted us to explore the potential for dormancy and its contribution to failed drug treatments in this infection. We document the development of non-proliferating intracellular amastigotes in vivo and in vitro in the absence of drug treatment. Non-proliferative amastigotes ultimately converted to trypomastigotes and established infections in new host cells.