Publications by authors named "Dylan M Ashton"
Background: Methodological heterogeneity hinders data comparisons across isolated studies of tendon and ligament properties, limiting clinical understanding and affecting the development and evaluation of replacement materials.
Purpose: To create an open-access data set on the morphological, biomechanical, and biochemical properties of clinically important tendons and ligaments of the lower limb, using consistent methodologies, to enable direct tendon/ligament comparisons.
Study Design: Descriptive laboratory study.
Tendon allograft and xenograft processing often involves one or more steps of freezing and thawing. As failure strength is an important graft consideration, this study aimed to evaluate effects on failure properties when varying freeze-thaw conditions. Kangaroo tendons, a potential xenograft source, were used to evaluate changes in ultimate tensile strength (UTS), failure strain and elastic modulus after exposure to different freezer-storage temperatures (-20°C vs.
View Article and Find Full Text PDFBackground: The use of allograft tendons has increased for primary and revision anterior cruciate ligament reconstruction, but allograft supply is currently limited to a narrow range of tendons and donors up to the age of 65 years. Expanding the range of donors and tendons could help offset an increasing clinical demand.
Purpose: To investigate the effects of donor age, sex, height, and specific tendon on the mechanical properties of a range of human lower leg tendons.
Article Synopsis
- Sex and joint injury are significant risk factors for developing osteoarthritis (OA), with mouse studies showing that males often experience worse outcomes than females.
- Various injury models, such as meniscal and ligament damage, were assessed in male and female mice to evaluate how these injuries impact joint mechanics and progression of post-traumatic OA (ptOA).
- The study found that while joint laxity was similar between sexes, females exhibited greater joint stiffness; however, the changes in joint mechanics due to injuries were not primarily responsible for the differences in ptOA severity between male and female mice.