Publications by authors named "Dylan Giorgino Riffert"
Article Synopsis
- Neurodegenerative diseases often involve the accumulation of TDP-43 protein in neurons, which leads to cytoplasmic inclusions associated with cell dysfunction.
- Researchers studied TDP-43 in hybrid cells (NSC-34) using advanced microscopy to observe changes in protein levels and aggregate formation over time, while also assessing oxidative stress and mitochondrial health.
- The study found that larger cytoplasmic inclusions of TDP-43 are primarily responsible for neuronal impairment, and it highlighted that while the proteasome and autophagy can target these inclusions, their effectiveness diminishes, preventing full recovery of neuronal function.
