Publications by authors named "Dylan De Bellis"
The rat is a useful laboratory model for respiratory diseases. SARS-CoV-2 proteins, such as the spike (S) protein, can induce inflammation. This study has investigated the ability of the Q498Y, P499T (QP-YT) amino acid change, described in the S-protein of the mouse-adapted laboratory SARS-CoV-2 MA strain, to interact with rat angiotensin converting enzyme-2 (ACE2) and stimulate responses in rat lungs.
View Article and Find Full Text PDFMitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploid due to aberrant mitosis. Previous studies have demonstrated that the activation and catalytic function of caspase-2 are key steps in MC to trigger apoptosis and/or cell cycle arrest of mitotically defective cells. However, the molecular mechanisms that regulate caspase-2 activation and its function are unclear.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the potential link between bolus intravenous (i.v.) fluid administration and acute lung injury using rat models, aiming to uncover the mechanisms involved.
- Healthy rats given saline i.v. showed increased lung water and inflammation, along with worse lung function, which was tied to the activation of TRPV4 channels.
- Findings indicated that blocking TRPV4 with ruthenium red reduced lung injury, suggesting that TRPV4 channel activation and endothelial inflammatory responses are key factors in fluid-induced lung edema.