Cooperative Demolition: Water's Disruption of Structures in Deep Eutectic Solvents.

We report a study of cooperativity in the transition from a nonaqueous deep eutectic solvent (DES) to an aqueous solution. In some systems, a nonequilibrium region prevails at low water contents, while cooperativity is always observed at high water contents. Catechol-based mixtures exhibit a Hill constant () of ∼ 3 and an overall Δ° of ca.