Publications by authors named "Dylan A Valencia"
Article Synopsis
- Actin cytoskeleton assembly is crucial for cell movement and muscle contraction, with formins being key proteins that help in the creation and maintenance of actin filaments.
- The FHOD-family of formins, particularly FHOD3L, is essential for developing sarcomeres in heart cells (cardiomyocytes), yet its precise functions are not fully understood.
- Research shows that FHOD3L is involved in nucleating and briefly elongating actin filaments, and its elongation activity is vital for proper sarcomere structure and function, which has implications for understanding heart muscle diseases.
Protein post-translational modifications (PTMs) can regulate biological processes by altering an amino acid's bulkiness, charge, and hydrogen bonding interactions. Common modifications include phosphorylation, methylation, acetylation, and ubiquitylation. Although a primary focus of studying PTMs is understanding the effects of a single amino acid modification, the possibility of additional modifications increases the complexity.
View Article and Find Full Text PDFActin is one of the most abundant proteins in eukaryotes. Discovered in muscle and described as far back as 1887, actin was first purified in 1942. It plays myriad roles in essentially every eukaryotic cell.
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