[Treatment of primary therapy refractory choriocarcinoma using the EMA-CO protocol].

This is a report on a 33 year old patient with a metastatic gestational choriocarcinoma. The patient was hospitalized with the picture of a spontaneous left kidney rupture and nephrectomy was performed. Under primary mono-dose methotrexate chemotherapy, the patient showed rapidly progressive metastases in both lungs, liver, right kidney and soft tissue.

[Adjuvant chemotherapy in dysgerminoma].

This is a report on a young patient with dysgerminoma of the right ovary. Right-side adnexectomy and hysterectomy were performed initially. Due to the clearly elevated tumour marker levels, indicating an involvement of other germ cell elements, we opted for postoperative chemotherapy instead of radiotherapy.

[Spontaneous kidney rupture].

Two cases of spontaneous rupture of the kidney are reported and the literature is reviewed. The clinical and pathological features of this uncommon disease and its treatment are discussed. In the first case the cause of retroperitoneal bleeding was a renal carcinoma, while in the second it was the result of renal metastases from gestational trophoblastic disease.

[Spindle cell sarcoma of the female breast].

Malignant mesenchymal breast tumors are extremely rare. Without cystosarcoma phylloides, the frequency of primary sarcomas is 0.6% of all neoplasms of the breast.

[Arterial regional chemotherapy of advanced breast cancer].

From October 1985 to November 1987, arterial regional chemotherapy with mitoxantrone was undertaken in 18 patients with primary far advanced carcinoma of the breast, of inflammatory or ulcerating type. Two patients had a bilateral carcinoma. Eight weeks after regional chemotherapy 18 of 20 tumours had become operable.

[HELLP syndrome: a life-threatening form of pre-eclampsia].

A rather unusual but dramatic form of EPH gestosis or pregnancy-induced hypertension is presented via the case of a 30-year old second gravida in the 30th week of pregnancy. This is a case of pre-eclampsia combined with haemolysis, elevated liver function tests and low platelet counts. Diagnostic features, pattern and pathophysiology are discussed with regard to international literature.