Publications by authors named "Dyana N Kenanova"
Article Synopsis
- Dysregulation of protein-protein interactions (PPIs) can lead to various diseases, prompting interest in methods to stabilize these interactions for drug discovery, especially with hub proteins like 14-3-3.
- Researchers employed disulfide tethering, a technique for finding small molecules that can reversibly bond to proteins, to identify selective PPI stabilizers, or "molecular glues," specifically targeting the 14-3-3σ hub protein.
- Through screening 14-3-3 complexes with five different phosphopeptides, they discovered stabilizing fragments for four of the complexes, with one fragment significantly enhancing the interaction between 14-3-3σ and C-RAF by 430-fold, paving
