Publications by authors named "Dyan M White"
Article Synopsis
- Physical stressors can lead to mitochondrial dysfunction and damage in individuals, particularly in people living with HIV (PWH) who experience chronic pain.
- The study investigated the mitochondrial responses of PWH with and without chronic pain using Quantitative Sensory Testing (QST) and measured various indicators of mitochondrial health before and after the test.
- Results indicated that PWH with chronic pain exhibited higher levels of mitochondrial reactivity, especially in terms of mtDNA damage and ND6 levels, suggesting they may be more vulnerable to conditions like cognitive decline linked to mitochondrial issues.
Background: Sex differences in pain sensitivity have been well documented, such that women often report greater sensitivity than men. However, clinical reports highlighting sex differences often equate gender and sex. This is a particularly critical oversight for those whose gender identity is different than their genetic sex.
View Article and Find Full Text PDFObjective: Chronic pain is increasingly recognized as a common and disabling problem for people living with HIV (PLWH). In a recent systematic review of psychosocial factors associated with chronic pain in PLWH, it was reported that very few studies to date have examined protective psychological factors that might help mitigate chronic pain for PLWH. The current study examined pain-specific resilience in relation to clinical and experimental pain, as well as pain coping in PLWH and chronic pain.
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- A study highlights the high rates of chronic pain among people living with HIV (PLWH) and the limited understanding of how psychosocial factors affect their pain outcomes, particularly the role of perceived injustice.
- The research aimed to investigate whether social support can lessen the negative impact of feeling unjustly treated on pain interference in daily life.
- Findings revealed that individuals with low social support experienced a stronger link between perceived injustice and pain interference, while those with higher social support showed less impact, suggesting that a supportive network could help reduce the detrimental effects of harmful beliefs about pain.
Chronic pain in persons living with HIV (PLWH) may be related to alterations in endogenous pain modulatory processes (e.g., high facilitation and low inhibition of nociception) that promote exaggerated pain responses, known as hyperalgesia, and central nervous system (CNS) sensitization.
View Article and Find Full Text PDF"Intersectional health-related stigma" (IHRS) refers to stigma that arises at the convergence of multiple health conditions. People living with HIV (PLWH) and chronic pain have two highly stigmatized health conditions, and thus may be at especially high risk for internalizing these stigmas and consequently experiencing depression. This study examined the intersectionality of internalized HIV and chronic pain stigma in relation to depressive symptoms in a sample of PLWH and chronic pain.
View Article and Find Full Text PDFObjective: Animal models have previously shown that HIV is associated with hyperalgesia, or heightened sensitivity to painful stimuli. Efforts to determine whether this finding translates to humans are presently lacking. Among persons living with HIV (PLWH), those with detectable viral loads may be at greatest risk for heightened pain sensitivity.
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