Interpretation of Nondiagnostic Vulvar Biopsies.

Objective: The aim of the study was to assess clinical and histopathologic characteristics of symptomatic women who underwent a nondiagnostic biopsy of the inner vulva.

Materials And Methods: Consecutive nondiagnostic biopsies from medial labia minora, posterior fourchette, and vestibule obtained from symptomatic women between 2011 and 2015 were reviewed for this retrospective histopathologic case series. Histopathologic assessment included site, basal layer appearance, lymphocytic infiltrate, and presence of fibrosis or sclerosis.

Can Routine Histopathology Distinguish Between Vulvar Cutaneous Candidosis and Dermatophytosis?

Objectives: This study aimed to determine if vulvar cutaneous candidosis and dermatophytosis can be distinguished by routine histopathology.

Materials And Methods: Twenty-four cases of periodic acid-Schiff-stained vulvar biopsies with a diagnosis of cutaneous mycosis were reviewed and histopathological characteristics on both periodic acid-Schiff and hematoxylin and eosin were recorded. Data were collected on age, clinical impression, microbiological results, and treatment, and all specimens underwent multiplex polymerase chain reaction analysis.

Squamoid eccrine ductal carcinoma of the scalp.

An 85-year-old man presented with an ulcerated pruritic nodule on the scalp. Histology of a deep curette specimen showed the typical features of a squamoid eccrine ductal carcinoma: superficial squamous differentiation and deep ductal structures.

Psoriasis superimposed on vitiligo: the tricolored vulva.

Objective: This study aimed to describe 2 cases of vulvar psoriasis and vitiligo resulting in a striking clinical appearance.

Materials And Methods: Case 1 was of a 41-year-old woman concerned about a dark pigmentation around the introitus. Case 2 was of an 80-year-old woman with vulvar itch and red, white, and brown areas.

Waldenström macroglobulinaemia presenting as tingling ulcers on the feet.

A 56-year-old man presented with tingling ulcers on the feet. On further skin examination, papules on the knees were observed. Biopsies revealed extravascular eosinophilic deposits of IgM, and Waldenström macroglobulinaemia was diagnosed.

Five patients with melanosis of the nipple and areola clinically mimicking melanoma.

Background: Pigmented lesions on the nipple and areola concern patients and physicians as melanoma and pigmented mammary Paget's disease must be considered in the differential diagnoses. There have been only six case reports of melanosis of the nipple and areola in the medical literature yet five cases presented to our department in a 26-month period.

Method: Five women aged between 26 and 34 years presented with pigmentation of the areola and/or nipple.

Development of a targeted risk-group model for skin cancer screening based on more than 100,000 total skin examinations.

Background: Skin cancer screening aims to detect potentially metastasizing skin cancers at an early and surgically curable stage. This may take the form of mass screening, as currently occurs in Germany, or of targeted screening of those at greatest risk.

Objective: To develop a model to identify patients at high risk of developing skin cancer who would benefit from regular skin cancer screening.

Treatment of warts at the turn of the millennium.

Gunpowder may no longer be a recommended treatment for warts, but most of the therapies used in 1950 are still used to some extent now. The problems, now as then, are the multiplicity of treatment options and the lack of a cure. Several treatments popular in the past decade are discussed.

Intralesional bleomycin.

The use of intralesional bleomycin to treat Bowen's disease of the palm affecting a motor mechanic is presented. Bleomycin in 1% lignocaine was injected at 3-6 week intervals to a cumulative total of 6.35 U.

Melasma of the forearms.

Melasma of the forearms seems to be a relatively common sign which is, to our knowledge, not reported in the literature. It seems that it may be more common in older patients and especially in postmenopausal women on supplementary oestrogen. The pigmentary change is macular and may be confluent or speckled.

Acrokeratoelastoidosis.

An indian woman presented with crateriform and pearly papules along the lines of transgredience of the hands and feet. Her father and an older sister are similarly affected. Histology showed hyperkeratosis and elastorrhexis.

Congenital malalignment of the great toenails.

A five year old boy is presented with bilateral congenital malalignment of the great toenails. This disorder is due to lateral deviation of the nail matrix and can be complicated by hemionychogryphosis or ingrowing of the nail at a young age.

Plantar wart presenting as a cutaneous horn.

An elderly man presented with a longstanding, tender lesion on the sole of the foot. Clinically this was a cutaneous horn but biopsy revealed the features of a viral wart. The cytopathic effects of cutaneous human papillomaviruses are discussed.

Cutaneous malignancies in renal transplant recipients from Nova Scotia, Canada.

Four hundred and seventy-four Nova Scotian renal transplant recipients were screened, using the records of the Nova Scotia Cancer Registry and the Victoria General Hospital, in a retrospective study, for the development of cutaneous malignancies. Sixteen patients developed a total of 60 squamous cell carcinomas (SCC) and 14 developed 28 basal cell carcinomas (BCC). The survival curve shows that within 10 years of transplant, less than 10% will develop SCC.

Fungal eosinophilic pustular folliculitis.

A young woman presented with a persistent unilateral erosive and pustular plaque of the forearm. Repeated biopsy was required to make the diagnosis of a fungal cause for her eosinophilic pustular folliculitis.