Publications by authors named "Dwayne A Breining"
Article Synopsis
- Bloodstream infections from HSV-1 and HSV-2 can have severe consequences, especially in newborns and immunocompromised individuals, highlighting the need for swift and accurate diagnostics.
- Current diagnostics are limited due to a lack of FDA-approved tests for detecting HSV in blood, as well as uncertainty regarding the best sample type to use.
- This study found that using serum samples for the modified Simplexa assay significantly outperforms whole blood in detecting HSV, demonstrating 100% positive agreement for detecting both HSV-1 and HSV-2, making serum a preferable option for rapid diagnosis.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), can be detected in respiratory samples by real-time reverse transcriptase polymerase chain reaction (RT-PCR) or other molecular methods. Accessibility of diagnostic testing for COVID-19 has been limited by intermittent shortages of supplies required for testing, including flocked nasopharyngeal (FLNP) swabs.
Methods: We developed a 3-dimensional printed nasopharyngeal (3DP) swab as a replacement of the FLNP swab.