Publications by authors named "Duygu Kasıkcı"
Objective: Pentoxifylline (PTX) has immunomodulatory properties and is known to reduce sepsis-associated infant mortality. We aimed to evaluate maternal oral and intra-amniotic administration of PTX for the prevention of fetal inflammation and injury in a caprine model.
Materials And Methods: Inflammation-mediated fetal injury was induced with maternal granulocyte-colony stimulating factor and intra-amniotic endotoxin at 0.
Article Synopsis
- The study aimed to create a new experimental model using maternal intravenous G-CSF and intra-amniotic endotoxin to induce fetal brain injury in preterm goat fetuses.
- Pregnant goats received G-CSF for five days, followed by a dose of endotoxin, and delivered preterm to collect fetal tissues for analysis.
- The results showed significant brain injury and inflammation, indicating that this model effectively simulated intrauterine inflammation in goats.