Publications by authors named "Duy M Le"
Article Synopsis
- Acute myeloid leukemia (AML) is difficult to treat due to its genetic diversity, protective tumor microenvironment, and immune evasion, making the search for effective therapies critical.
- The inhibitor JNJ-75276617 (bleximenib) targets the menin-KMT2A interaction, showing promise in preclinical studies by impairing cell growth and promoting differentiation in AML cells, particularly in specific genetic subtypes.
- Treatment with JNJ-75276617 leads to epigenetic changes that enhance the expression of MHC class I and II, which could improve the effectiveness of T cell-mediated therapies against leukemia.
Lattice dynamics and self-trapped excitons in the CsSnBrdouble perovskites.
J Phys Condens Matter
April 2024
Our study delved into the detailed investigation of CsSnBrdouble perovskites, focusing on their electrical properties, lattice dynamics, and stability. The direct bandgap for CsSnBrwas estimated to be at 2.93 eV.
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- * It utilized three adult AML patient cohorts to analyze gene expression, discovering that high levels of a specific gene are connected to shorter survival post-HSCT.
- * This gene's expression also enhances risk assessment and is associated with specific biological pathways and an immune environment that may influence treatment response in AML.
Background: Mineral elements present in lignocellulosic biomass feedstocks may accumulate in biorefinery process streams and cause technological problems, or alternatively can be reaped for value addition. A better understanding of the distribution of minerals in biomass in response to pretreatment factors is therefore important in relation to development of new biorefinery processes. The objective of the present study was to examine the levels of mineral elements in pretreated wheat straw in response to systematic variations in the hydrothermal pretreatment parameters (pH, temperature, and treatment time), and to assess whether it is possible to model mineral levels in the pretreated fiber fraction.
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