Combined Cell-Free DNA Screening for Aneuploidies and Selected Single-Gene Disorders for Pregnancies With Sonographically Detected Fetal Anomalies: Detection Rate and Residual Risk.

Objectives: To determine the additional detection rate (DR) and the residual risk (RR) of combined cell-free DNA (cfDNA) screening for aneuploidies (not including copy number variants) and 25 dominant single-gene disorders (SGD) in pregnancies with sonographic abnormalities.

Method: One hundred sixteen singleton pregnant women with abnormal fetal ultrasounds from week 12 were included in the study. They underwent combined cfDNA analysis, while exome sequencing and karyotyping were performed as reference standards.

Optimization and inventory management under stochastic demand using metaheuristic algorithm.

This study considers multi-period inventory systems for optimizing profit and storage space under stochastic demand. A nonlinear programming model based on random demand is proposed to simulate the inventory operation. The effective inventory management system is realized using a multi-objective grey wolf optimization (MOGWO) method, reducing storage space while maximizing profit.

Seaport throughput forecasting and post COVID-19 recovery policy by using effective decision-making strategy: A case study of Vietnam ports.

This study deals with the dynamic interactions between seaports and decision-making strategy for seaport operations by utilizing four-dimensional fractional Lotka-Volterra competition model under frequently disrupted by time-delay factor. Nonlinear analysis methods, including equilibrium analysis, stability evaluation, and time series investigation, are intensely explored to describe the cooperation and competition dynamics in maritime logistics. The dynamical analysis indicates that the port competition system shows a complex and highly nonlinear behaviour, notably illustrating unstable equilibria and even chaotic phenomena.

Enhanced third harmonic generation in ultrathin free-standing β-GaO nanomembranes: study on surface and bulk contribution.

Third harmonic generation (THG) has proven its value in surface and interface characterization, high-contrast bio-imaging, and sub-wavelength light manipulation. Although THG is observed widely in general solid and liquid substances, when laser pulses are focused at nanometer-level ultra-thin films, the bulk THG has been reported to play the dominant role. However, there are still third harmonics (TH) generated at the surface of the thin-films, not inside the bulk solid - so-called surface TH, whose relative contribution has not been quantitatively revealed to date.

Self-assembled kanamycin antibiotic-inorganic microflowers and their application as a photocatalyst for the removal of organic dyes.

Construction of hybrid three-dimensional (3D) hierarchical nanostructures via self-assembly of organic and inorganic compounds have recently attracted immense interest from scientists due to their unique properties and promise in a large range of applications. In this article, hybrid flower structures were successfully constructed by self-assembly an antibiotic, kanamycin, with Cu. The flower-like morphology was observed by scanning electron microscopy, to be approximately 4 µm in diameter and about 10 nm in thickness.

Determination of optimal loading and maintenance doses for continuous infusion of vancomycin in critically ill patients: Population pharmacokinetic modelling and simulations for improved dosing schemes.

Objectives: Despite extensive clinical use, limited data are available on optimal loading and maintenance doses of vancomycin in critically ill patients. This study aimed to develop a rational approach for optimised dosage of vancomycin given in a continuous infusion in critically ill patients.

Methods: Vancomycin pharmacokinetic (PK) data (total serum concentrations) were obtained from 55 intensive care unit (ICU) patients (Bach Mai Hospital, Hanoi, Vietnam) receiving a 20 mg/kg loading dose followed by continuous infusion stratified by creatinine clearance (CLCr).

The Association Between Gender Inequalities and Women's Utilization of Maternal Health Services: A Cross-Sectional Survey in Eight South Central Coast Provinces, Vietnam.

Background: Gender inequalities influence the utilization of maternal health services in Vietnam, but little research has been published. This study, therefore, aimed to explore the association between gender inequalities and women's utilization of maternal health services in Vietnam.

Methods: The study was conducted in 8 provinces in the South Central Coast region of Vietnam during August 2013 to May 2014.

Analysis of the cause of recurrent pregnancy loss in Vietnam: A cross-sectional study.

Recurrent pregnancy loss (RPL) is a physical and mental burden for women. In Vietnam, exploring the cause of miscarriages is still a challenge to clinical physicians. We aimed to investigate the etiology of RPL in the National Hospital of Obstetrics and Gynecology in Vietnam from 2012 to 2014.