A novel large deletion in the APC gene associated with Gardner syndrome in a Chinese family.

Introduction: Gardner syndrome is a hereditary disease characterized by familial adenomatous polyposis (FAP), accompanied by soft tissue tumors.

Material And Methods: a Chinese FAP family was enrolled and followed-up for three years.

Results: a novel large germline fragment deletion (EX10_16DEL) of the adenomatous polyposis coli (APC) gene was identified by multiplex ligation-dependent probe amplification (MLPA).

Progress in inflammasome activation and pyrolysis in alcoholic liver disease.

Alcoholic liver disease (ALD) is a chronic liver disease characterized by large accumulation of lipids in the liver, accompanied by inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma. In the different stages of ALD, mediators of the immune system, such as cytokines or inflammasomes, are crucially involved. In the ALD disease spectrum, the upregulation of the inflammatory cascade is the main factor in the development of steatohepatitis into severe alcoholic hepatitis.

A case report of gastric amyloidosis due to multiple myeloma mimicking gastric cancer.

Background: Gastrointestinal (GI) amyloidosis is a rare complication of multiple myeloma (MM). Due to its nonspecific clinical presentation and endoscopic appearance, an early and accurate diagnosis of GI amyloidosis is difficult. Here, we report a case of GI amyloidosis due to MM, which initially presented as GI manifestations mimicking gastric cancer.

Role of potassium channels in regulation of rat coronary arteriole tone.

Activity of potassium (K(+)) channels plays a key role in regulating arterial tone and therefore blood flow. But little is known about the roles of K(+) channels in the coronary arterioles. The aim of the present study was to investigate the influences of several potassium channel blockers on resting vascular tone in isolated rat coronary arteriole.

Tanshinone II(A) elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels.

Salvia miltiorrhiza has been widely used in the treatment of various cardiovascular diseases due to its ability to improve coronary microcirculation and increase coronary blood flow. Tanshinone II(A), the major active lipophilic ingredient responsible for the beneficial actions of Salvia miltiorrhiza, was shown to induce vasodilation in coronary arteries. But its effects on coronary arterioles remain unknown.