Prevalence of Hypertrophic Cardiomyopathy and ALMS1 Variant in Sphynx Cats in New Zealand.

Recently, hypertrophic cardiomyopathy (HCM) in Sphynx cats has been associated with a variant in the gene encoding Alström syndrome protein 1 (ALMS1). The primary aims of this study were to describe the prevalence of HCM in Sphynx cats in New Zealand, and to assess the association between HCM and the ALMS1 variant in this population. In this prospective study, 55 apparently healthy Sphynx cats from registered Sphynx breeders and pet owners in New Zealand were screened by a cardiologist.

Do conservatives really have an advantage in mental health? An examination of measurement invariance.

Many studies have found that conservatives show an advantage in mental health and happiness and various causes of this have been debated (e.g., religiousness, ideology, or genetics).

Sex and national differences in internet addiction in Egypt and Saudi Arabia.

Background: Understanding individual differences in psychology, and how they relate to specific addictions, may allow society to better identify those at most risk and even enact policies to ameliorate them. Internet addiction is a growing health concern, a research focus of which is to understand individual differences and the psychology of those most susceptible to developing it. Western countries are strongly overrepresented in this regard.

International differences in the speed of cognitive development: A systematic examination of the existence of the Simber Effect.

The Simber Effect refers to the phenomenon whereby, in Arabic countries, young children have an IQ that is little different from that of Western children but that these differences increase throughout childhood culminating in a difference of around 20 points by adulthood. The true nature of this phenomenon is revealed by an examination of 125 samples from all around the globe measured with Raven's Progressive Matrices. We show that in many cases different speeds of cognitive development increase the IQ score differences between countries mostly between 4 and 9 years of age, and that these increases can in part be explained by poor environmental conditions.

Differences in Left Ventricular Enlargement Secondary to Chronic Volume Loading Between English Springer Spaniels and Two Similar Sporting Breeds.

Introduction: English springer spaniels have larger, rounder ventricles than most other breeds. How this geometry impacts responses to volume overload remains unknown. We compared left ventricular size between English springer spaniels and two similarly sized sporting breeds (Border collies and Labrador retrievers) in naturally occurring chronic left ventricular volume loading conditions (mitral regurgitation and patent ductus arteriosus [PDA]) to examine whether differences in remodelling responses exist between these breeds.

Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages.

The lymph node (LN) is home to resident macrophage populations that are essential for immune function and homeostasis, but key factors controlling this niche are undefined. Here, we show that fibroblastic reticular cells (FRCs) are an essential component of the LN macrophage niche. Genetic ablation of FRCs caused rapid loss of macrophages and monocytes from LNs across two in vivo models.

The General Factor of Personality (GFP) is associated with higher salary, having a leadership position, and working in a social job.

Previous studies have suggested that a general factor exists at the top of the hierarchal structure of personality. One interpretation of this General Factor of Personality (GFP) is that it reflects social effectiveness. Accordingly, in a large employee sample (N = 1267), we tested whether the GFP relates to several outcomes assumed to be linked with social effectiveness.

Decreases in divergent thinking across age groups from 2005 to 2018 amongst school children in Sudan.

Performances on tests of creativity have been found to be in decline in the USA. Here, we explore scores on divergent thinking tests in private schools in Khartoum State in Sudan by comparing a 2005 and a 2018 administration of the Torrance Standardized Circles test to 8- to 12-year-olds of both sexes. We find a decline across the period in all three dimensions of the test (Fluency, Flexibility and Originality), as well as in the overall index of divergent thinking.

"Blessed are the Nations with High Levels of Schizophrenia": National Level Schizophrenia Prevalence and Its Relationship with National Levels of Religiosity.

Schizophrenia is correlated with religious delusions but, heretofore, the relationship between schizophrenia prevalence and religiosity has not been explored at the national level. Examining this relationship, we find that national level schizophrenia prevalence is correlated with national level religiosity and strongly negatively correlated with national level atheism across 125 countries. When controlling for cognitive performance and economic development in multiple regression analyses, the proportion of the variance explained was 2.

The Negative Religiousness-IQ Nexus is a Jensen Effect on Individual-Level Data: A Refutation of Dutton et al.'s 'The Myth of the Stupid Believer'.

A recent study by Dutton et al. (J Relig Health 59:1567-1579. https://doi.

Echocardiographic reference intervals in healthy UK deerhounds and prevalence of preclinical dilated cardiomyopathy: a prospective, longitudinal study.

Background: Sighthounds have high echocardiographic (ECHO) left ventricular volumes. Establishing robust breed-specific ECHO reference intervals (RI) for screening is important. End-diastolic volume index (EDVI), end-systolic volume index (ESVI) and ejection fraction (EF) reference ranges derived by Simpson's method of discs are not available for deerhounds.

Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death.

End-stage kidney disease (ESKD) patients are at high risk of severe COVID-19. We measured 436 circulating proteins in serial blood samples from hospitalised and non-hospitalised ESKD patients with COVID-19 (n = 256 samples from 55 patients). Comparison to 51 non-infected patients revealed 221 differentially expressed proteins, with consistent results in a separate subcohort of 46 COVID-19 patients.

Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease.

Background: Treatment is indicated in dogs with preclinical degenerative mitral valve disease (DMVD) and cardiomegaly (stage B2). This is best diagnosed using echocardiography; however, relying upon this limits access to accurate diagnosis.

Objectives: To evaluate whether cardiac biomarker concentrations can be used alongside other clinical data to identify stage B2 dogs.

Spare the rod and spoil the group's cultural fitness? Conditions under which corporal punishment leads to detrimental and beneficial outcomes.

Corporal punishment of children is common across human history, and the specific practice of striking the buttocks, known as spanking, seems to have developed independently across a number of separate cultures. This pattern suggests adaptive value, posing a paradox in view of the many reviews stating that spanking has purely negative outcomes on future mental health, and the recommendation of the American Academy of Pediatrics that it be outlawed. We purport to resolve this paradox by separating this particular type of corporal punishment from less controlled lashing out in anger, and we reanalyze these reviews in terms of psychological and physical health outcomes.

Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues.

The OX40-OX40L pathway provides crucial co-stimulatory signals for CD4 T cell responses, however the precise cellular interactions critical for OX40L provision in vivo and when these occur, remains unclear. Here, we demonstrate that provision of OX40L by dendritic cells (DCs), but not T cells, B cells nor group 3 innate lymphoid cells (ILC3s), is critical specifically for the effector Th1 response to an acute systemic infection with Listeria monocytogenes (Lm). OX40L expression by DCs is regulated by cross-talk with NK cells, with IFNγ signalling to the DC to enhance OX40L in a mechanism conserved in both mouse and human DCs.

Identification of Murine and Human Innate Lymphoid Cells in Frozen Tissue Sections Using Immunofluorescence.

ILCs interact with multiple cell types within their local environment to integrate a wealth of different signals into coordinated responses that regulate tissue homeostasis as well as immune responses upon challenge. While the development and function of ILCs has been extensively studied, principally using flow cytometry, there is limited understanding of the precise composition of cellular niches within which ILCs reside. While this might be optimally studied using dynamic live imaging approaches, immunofluorescence staining of tissue sections can provide fundamental basic information regarding the nature of these microenvironments.

Identification of Murine Innate Lymphoid Cell Subsets in Barrier Tissues and Their Draining Lymph Nodes Using Flow Cytometry.

Innate lymphoid cells (ILCs) are present in most tissues within the body but have been most extensively studied within mucosal barriers such as the lung and intestine. Isolation of immune cells from such tissues requires enzymatic digestion, and the number and composition of the cells released are dependent upon robust protocols tailored to the tissue of study. Here, detailed methodologies to isolate ILCs from various barrier sites and their draining lymph nodes (LNs) are described.

The Myth of the Stupid Believer: The Negative Religiousness-IQ Nexus is Not on General Intelligence (g) and is Likely a Product of the Relations Between IQ and Autism Spectrum Traits.

Numerous studies have found a negative relationship between religiousness and IQ. It is in the region of - 0.2, according to meta-analyses.

The effect different substrates have on the trueness and precision of eight different intraoral scanners.

Objective: This in vitro study compares the newest generation of intraoral scanners to their older counterparts, and tests whether material substrates affect the trueness and precision of intraoral scanners (IOS).

Material And Methods: A custom model, used as the reference standard, was fabricated with teeth composed of different dental materials. The reference standard scan was obtained using a three-dimensional (3D) optical scanner, the ATOS III.

Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations.

Tissue residency is considered a defining feature of the innate lymphoid cell (ILC) populations located within mucosal and adipose tissues. ILCs are also present within all lymphoid tissues, but whether ILCs migrate between lymphoid and nonlymphoid sites and in what context is poorly understood. To determine whether migratory ILCs exist within peripheral lymph nodes (LNs), we labeled all cells within the brachial LN (bLN) of transgenic mice expressing a photoconvertible fluorescent protein by direct exposure to light.

Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.

Intestinal immune homeostasis is dependent upon tightly regulated and dynamic host interactions with the commensal microbiota. Immunoglobulin A (IgA) produced by mucosal B cells dictates the composition of commensal bacteria residing within the intestine. While emerging evidence suggests the majority of IgA is produced innately and may be polyreactive, mucosal-dwelling species can also elicit IgA via T cell-dependent mechanisms.

National, Sex and Academic Discipline Difference in Smartphone Addiction: A Study of Students in Jordan, Saudi Arabia, Yemen and Sudan.

There are an increasing number of studies on smartphone addiction (SA) among students, and also a number of cross-cultural ones. We add to this body of research by presenting, for the first time, a cross-cultural study comparing students in four Middle Eastern countries: Sudan, Jordan, Saudi Arabia, and Yemen. In this context, we also attempt to replicate findings-in other studies-that there are differences in smartphone addiction prevalence along the lines of sex, culture and subject of study.

Sinistrality is associated with (slightly) lower general intelligence: A data synthesis and consideration of the secular trend in handedness.

The relationship between the general factor of intelligence (g) and handedness is investigated using a combined sample of 23511 respondents from three large databases: the NLSY'79 (US), NLSY'97 (US) and NCDS (UK). Dextrals - those who use their right hands were found to be 1.22 IQ points higher than sinistrals (left handers) after controlling for sex and age and correcting for sources of measurement error.

REGIONAL DIFFERENCES IN INTELLIGENCE IN EGYPT: A COUNTRY WHERE UPPER IS LOWER.

Two administrations of the Coloured Progressive Matrices in Egypt were compared. The first was administered to a large, representative national sample between 2011 and 2013. The second was administered to primary school pupils in villages in Menoufia in northern Egypt in 2017.

An update on canine cardiomyopathies - is it all in the genes?

Dilated cardiomyopathy is the second most common cardiac disease in dogs and causes considerable morbidity and mortality. Primary dilated cardiomyopathy is suspected to be familial, and genetic loci have been associated with the disease in a number of breeds. Because it is an adult-onset disease, usually with late onset, testing breeding dogs and bitches before breeding for a genetic mutation that could lead to dilated cardiomyopathy would be helpful to prevent disease.