Publications by authors named "Dustine Reich"
Article Synopsis
- The study explored the effect of perampanel, an AMPA receptor antagonist, on reducing hyperexcitability around gliomas, which could promote tumor growth.
- An open-label trial compared perampanel with standard care in patients with high-grade glioma undergoing surgery, measuring outcomes like high-frequency oscillation rates and seizure occurrence.
- Results showed no significant difference in hyperexcitability outcomes between perampanel and standard care, and early termination of the trial indicated similar seizure rates and overall survival for both treatments.
Article Synopsis
- The study investigated the effects of the AMPA receptor antagonist perampanel on hyperexcitability and clinical outcomes in patients undergoing surgery for high-grade glioma.
- The trial compared perampanel to standard care using levetiracetam, measuring intraoperative hyperexcitability through high-frequency oscillation (HFO) rates and tracking seizure-free outcomes and overall survival.
- Results indicated no significant difference in hyperexcitability or survival outcomes between the two treatments, leading to the early termination of the trial due to futility, while perampanel was found to be safe and well-tolerated.
Objective: Postictal psychiatric symptoms (PPS) are a relatively common but understudied phenomenon in epilepsy. The mechanisms by which seizures contribute to worsening in psychiatric symptoms are unclear. We aimed to identify PPS prospectively during and after admission to the epilepsy monitoring unit (EMU) in order to characterize the postictal physiologic changes leading to PPS.
View Article and Find Full Text PDFImplantation of electrodes in the brain has been used as a clinical tool for decades to stimulate and record brain activity. As this method increasingly becomes the standard of care for several disorders and diseases, there is a growing need to quickly and accurately localize the electrodes once they are placed within the brain. We share here a protocol pipeline for localizing electrodes implanted in the brain, which we have applied to more than 260 patients, that is accessible to multiple skill levels and modular in execution.
View Article and Find Full Text PDFObjective: The association between postictal electroencephalogram (EEG) suppression (PES), autonomic dysfunction, and Sudden Unexpected Death in Epilepsy (SUDEP) remains poorly understood. We compared PES on simultaneous intracranial and scalp-EEG and evaluated the association of PES with postictal heart rate variability (HRV) and SUDEP outcome.
Methods: Convulsive seizures were analyzed in patients with drug-resistant epilepsy at 5 centers.