Publications by authors named "Dustin M Brown"
Metformin (MET) is increasingly implicated in reducing the incidence of multiple cancer types in patients with diabetes. However, similar effects of MET in non-diabetic women with endometrial cancer (EC) remain unknown. In a pilot study, obese non-diabetic women diagnosed with type 1, grade 1/2 EC, and consenting to participate were randomly assigned to receive MET or no MET (control (CON)) during the pre-surgical window between diagnosis and hysterectomy.
View Article and Find Full Text PDFArticle Synopsis
- - Millions of women struggle with both type 1 diabetes mellitus and endometriosis, which can complicate diagnosis and treatment due to the asymptomatic nature of these conditions in their early stages.
- - There is a growing understanding of the causes of both diseases, but their co-existence has not been widely explored, leading to gaps in medical awareness and care.
- - The review highlights the potential benefits of integrating knowledge about co-morbidity into treatment plans, aiming to improve therapies and reduce complications for affected women.
Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of ME1 (ME1-Tg mice) with Apc mice to obtain male Apc/ME1-Tg mice. ME1 protein levels were significantly greater within gut epithelium and adenomas of male Apc/ME1-Tg than Apc mice.
View Article and Find Full Text PDFContext: Progesterone (P) resistance is a hallmark of endometriosis, but the underlying mechanism(s) for loss of P sensitivity leading to lesion establishment remains poorly understood.
Objective: To evaluate the association between Notch-1 signaling activation and P resistance in the progression of endometriosis.
Design: Case control study; archived formalin-fixed, paraffin-embedded tissues.