Publications by authors named "Dustin Duffy"
Article Synopsis
- Carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) are serious public health threats, particularly those that produce carbapenemases, which makes them resistant to many antibiotics.
- Analysis of data from the Antimicrobial Resistance Laboratory Network (AR Lab Network) from 2018 to 2022 revealed that among the tested isolates, 35% were single-carbapenemase producing (SCP) and only 1% were multiple-carbapenemase producing (MCP).
- The proportion of MCP-CRE detections has shown a gradual increase, indicating the need for ongoing monitoring and research efforts to tackle these dangerous bacteria.
Article Synopsis
- - The study evaluated the safety and effectiveness of semaglutide, a diabetes and weight loss medication, in patients with advanced chronic kidney disease (CKD) stages 4 and 5, as well as those on dialysis, due to limited existing research in this area.
- - Data from 76 patients (mostly males with a mean age of 66.8) was analyzed over approximately five years, showing significant weight loss (avg. drop of 4.9 kg) and decreased hemoglobin A1c levels (avg. drop from 8.0% to 7.1%).
- - While 63.1% reported no adverse effects, the most common issues leading to discontinuation were nausea, vomiting,
Article Synopsis
- - The study analyzes the outcomes of kidney transplant candidates with obesity who underwent sleeve gastrectomy (SG) to qualify for transplantation, showing significant weight loss post-surgery.
- - Among 54 patients who had SG, 37% were listed for a kidney transplant, and 20 received a transplant, compared to lower rates in a nonsurgical group (14% listed, 10% transplanted).
- - While SG resulted in effective weight loss and improved transplant rates, it also carried risks of complications and functional decline, indicating a need for further safety and efficacy research.
Background: There is limited evidence and lack of guidelines for diagnostic laboratory evaluation of patients with possible multiple sclerosis (MS).
Objective: To survey neurologists on their practice of laboratory testing in patients with possible MS.
Methods: An online survey was developed to query the frequency of serum and cerebrospinal fluid (CSF) studies ordered in the routine evaluation of patients with possible MS, and in three hypothetical clinical cases.
Background: Stiff person spectrum disorder (SPSD) is heterogeneous, and accurate diagnosis can be challenging.
Methods: Patients referred for diagnosis/suspicion of SPSD at the Mayo Autoimmune Neurology Clinic from July 01, 2016, to June 30, 2021, were retrospectively identified. SPSD diagnosis was defined as clinical SPSD manifestations confirmed by an autoimmune neurologist and seropositivity for high-titer GAD65-IgG (>20.
Background: Pneumocystis jirovecii pneumonia (PJP) is a potentially fatal infection afflicting the immunocompromised population, including solid organ transplant (SOT) recipients. Several risk factors have been described; however, little is known regarding the risk of PJP in SOT recipients with posttransplant lymphoproliferative disorder (PTLD).
Methods: We performed a nested case-control study of SOT recipients diagnosed with PJP from 2000 to 2020.
Article Synopsis
- - The study investigated the incidence of nocardiosis, an infection affecting immunocompromised solid organ transplant recipients, finding that 2.65% of these patients are at risk for developing it, yet limited research exists on preventive measures.
- - Researchers conducted a case-control study involving 123 SOT recipients with confirmed nocardiosis and 245 matched uninfected controls, discovering several risk factors like elevated immunosuppressant levels and a lack of specific prophylaxis were associated with the infection.
- - Results showed that the use of trimethoprim-sulfamethoxazole prophylaxis significantly reduced the odds of developing nocardiosis and increased the risk of 12-month mortality in infected patients, highlighting the importance of
Background: MS is the most common CNS inflammatory demyelinating disease. Plasma exchange (PLEX) has well-demonstrated efficacy in acute corticosteroid-refractory attacks of demyelination but identifying the factors that predict favorable PLEX response remains elusive. We aimed to determine if apparent diffusion coefficient (ADC) restriction on brain MRI predicts clinical response to PLEX in individuals with an acute cerebral attack of MS.
View Article and Find Full Text PDFLarge pericardial effusion (LPE) and tamponade are purported manifestations associated with atypical chronic graft-versus-host disease (cGVHD); however, their temporal association with GVHD, management, and impact on overall outcome are not well established. We report a retrospective analysis of 38 patients who developed LPE from a cohort of 1265 (3.00%) patients age ≥18 years who underwent allogeneic hematopoietic cell transplantation (alloHCT) at Mayo Clinic between March 1993 and August 2020.
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