Publications by authors named "Dusti Folger"
Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection.
Am J Physiol Lung Cell Mol Physiol
July 2009
Article Synopsis
- - Patients with mutations in the SP-C gene face severe lung issues, particularly during viral infections like RSV, leading to worsened symptoms in SP-C-deficient mice compared to those with normal SP-C.
- - These SP-C-deficient mice exhibited prolonged lung inflammation and higher levels of white blood cells associated with infection, persisting for up to 30 days after RSV infection.
- - The study found that SP-C deficiency enhances inflammatory responses via increased expression of TLR3, which can be regulated by purified SP-C and synthetic phospholipids, suggesting a potential area for therapeutic intervention.