Publications by authors named "Dusenge Marie Aimee"
Article Synopsis
- A study compared the effects of a new sonic irrigation system called Easydo Activator (EA) on sealer penetration at the root apex to traditional irrigation methods: needle irrigation (NI) and passive ultrasonic irrigation (PUI).
- Forty-two single-rooted teeth were divided into three groups for different irrigation treatments, followed by analysis using confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) to assess sealer penetration and smear layer removal.
- The results showed that EA outperformed both NI and PUI in terms of greater sealer penetration area, depth, and lower smear layer scores, suggesting it could enhance clinical root canal therapy.
Regarding past epidemiological studies, there has been disagreement over whether type 1 diabetes (T1DM) is one of the risk factors for dental caries. The purpose of this study was to determine the causative links between genetic susceptibility to T1DM, glycemic traits, and the risk of dental caries using Mendelian randomization (MR) approaches. Summary-level data were collected on genome-wide association studies (GWAS) of T1DM, fasting glucose (FG), glycated hemoglobin (HbA1c), fasting insulin (FI), and dental caries.
View Article and Find Full Text PDFObjectives: The current research on single-nucleotide polymorphism (SNP) mutation sites at different positions of the FAM83H gene and their phenotypic changes leading to amelogenesis imperfecta (AI) is inconsistent. We identified a previously reported heterozygous nonsense mutation c.1192C>T (p.
View Article and Find Full Text PDFThere are considerable socioeconomic costs associated with bone defects, making regenerative medicine an increasingly attractive option for treating them. Chitosan is a natural biopolymer; it is used in approaches for sustained slow release and osteogenesis, and metformin has osteoinductivity. Our study aimed to synthesize chitosan and human serum albumin (HSA) with a metformin nanoformulation to evaluate the therapeutic effects of this nanoformulation on bone defects .
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- The study examined the link between the oral microbiota and COVID-19, aiming to evaluate how oral bacteria diversity differs in infected patients compared to healthy individuals.
- Researchers systematically reviewed data from multiple scientific databases, focusing on the diversity and composition of oral microbiota in people with confirmed SARS-CoV-2 infection versus healthy controls, while also analyzing the expression of a key protein receptor (DPP4) related to the virus.
- Results showed infected patients had lower oral microbiota diversity, especially among older adults, with particular bacteria genera (e.g., Streptococcus and Neisseria) showing significant abundance changes; additionally, lower DPP4 expression in older individuals correlated negatively with viral gene expression.
Kangfuxin (KFX) shows potential in wound healing, but its role in socket healing is unclear. This research finds increased bone mass, mineralization, and collagen deposition in KFX-treated mice. Mouse bone marrow mesenchymal stem cells, human periodontal ligament stem cells (hPDLSCs), and human dental pulp stem cells (hDPSCs) are treated with KFX under osteogenic induction.
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- - The article discusses the challenges of treating jaw-bone defects caused by diseases, emphasizing the need for better reconstruction methods through bone tissue engineering using oral cavity-derived stem cells.
- - It reviews current research on the effectiveness of various types of stem cells and jaw-bone defect models, highlighting their respective advantages and disadvantages.
- - The conclusion suggests that the choice of cell type and animal model should align with the specific goals of research and the nature of the disease, providing groundwork for future tissue engineering studies.
Background: As periodontitis progresses, the oral microbiota community changes dynamically. In this study, we evaluated the dominant bacteria and their roles in the potential pathway in young males with stage III periodontitis.
Methods: 16S rRNA sequencing was performed to evaluate variations in the composition of oral bacteria between males with stage I and III periodontitis and identify the dominant bacteria of each group.
The oral microbiome in young women at different stages of periodontitis: dominant in stage III periodontitis.
Front Cell Infect Microbiol
December 2022
Objective: Periodontitis progression is related to the dynamic dysbiosis of oral microbiome. We identified the dominant bacteria and the potential pathway in young women with stage-III periodontitis.
Materials And Methods: Samples of subgingival plaque were collected from 26 young women with periodontitis (20 with stage-I and 6 with stage-III).
Article Synopsis
- This study compares sonic irrigation (SI) and conventional needle irrigation (CNI) for enhancing sealer penetration in root canal treatments, aiming to determine which is more effective.
- A systematic review and meta-analysis, using data from various medical databases, found that SI resulted in significantly better sealer penetration in the coronal and middle segments of teeth, while the apical segment showed mixed results.
- Overall, the findings suggest that SI improves sealing ability in dental treatments, particularly in the upper areas of dentin, indicating its potential as a preferable technique in clinical practice.
Bone tissue engineering (BTE) is a promising method for the repair of difficult-to-heal bone tissue damage by providing three-dimensional structures for cell attachment, proliferation, and differentiation. Traditional Chinese medicine (TCM) has been introduced as an effective global medical program by the World Health Organization, comprising intricate components, and promoting bone regeneration by regulating multiple mechanisms and targets. This study outlines the potential therapeutic capabilities of TCM combined with BTE in bone regeneration.
View Article and Find Full Text PDFThe immunological response occurring during periapical inflammation includes expression of nucleotide binding oligomerization domain containing 2 and hepcidin. Nucleotide binding oligomerization domain containing 2 deficiency increases infiltration of inflammatory cells close to alveolar bone. Hepcidin has an important role in iron metabolism affecting bone metabolism.
View Article and Find Full Text PDFPeriodontitis is a globally prevalent disease that imposes a functional and aesthetic burden on patients. The oral microbiome influences human health. The aim of this study was at assessing gender variation in the subgingival bacterial microbiome of elderly patients with initial periodontitis and to determine the causes of this variation.
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- The study investigates gender differences in the oral microbiomes of youths with severe periodontitis by analyzing subgingival plaque samples from 17 patients (11 males, 6 females).
- Using 16S rRNA gene sequencing, researchers compared microbiome composition and diversity while applying statistical analyses like LEfSe to identify specific bacteria in each group.
- Results revealed that males had higher overall microbial diversity and different dominant bacteria compared to females, with implications for understanding how these differences may affect immune responses and periodontitis progression.