Publications by authors named "Dusanka Franic"
Article Synopsis
- - The study investigates how childhood trauma (CT) and the FKBP5 gene, a key regulator of stress responses, are linked to psychosis by examining FKBP5 methylation patterns in different participant groups.
- - A total of 144 participants were analyzed: 48 with psychotic disorders, 50 unaffected siblings, and 46 healthy controls, assessing CT through a questionnaire and conducting genetic testing.
- - Results showed that individuals with a specific FKBP5 gene variant (the T allele) had reduced methylation levels in those with psychosis, suggesting a connection between genetic factors and HPA axis activity influenced by childhood trauma.
Inflammation plays a critical role in pathogenesis of depression and can affect the hypothalamic-pituitary-adrenal axis activity. Accordingly, in this study we investigated the role of hippocampal glucocorticoid receptor in mediating the effects of inflammation on behaviour of female and male Wistar rats. We studied the effects of lipopolysaccharide on the levels of glucocorticoid receptors and its co-chaperones FK506 binding protein 52 and FK506 binding protein 51, the levels of glucocorticoid receptor phospho-isoforms, pGR-232 and pGR-246, and glucocorticoid receptor up-stream kinases.
View Article and Find Full Text PDFRationale: Inflammation plays a key role in the pathogenesis of major depressive disorder (MDD) for a subset of depressed individuals. One of the possible routes by which cytokines can induce depressive symptoms is by promoting the dysregulation of hypothalamic-pituitary-adrenal (HPA) axis via altering glucocorticoid receptor (GR) function.
Objectives: We investigated the mechanisms that finely tune the GR functioning upon lipopolysaccharide (LPS), i.