Bio-preservative potential of marjoram and fennel essential oil nano-emulsions against toxigenic fungi in citrus: integrating , -, and - approaches.

Citrus fruits, known for their vibrant flavours and health benefits, are susceptible to fungal attacks, particularly from toxigenic fungi, which pose a significant pre- and post-harvest hazard. However, aromatic oils and their nanoparticles may effectively address this issue. Marjoram and fennel oils, alongside their nanoparticles, were extracted, and their aromatic constituents and antimicrobial activities were evaluated.

Marrow Adiposity Content and Composition Are Not Associated With Incident Fragility Fractures in Postmenopausal Women: The ADIMOS Fracture Study.

Context: Noninvasive measurement of bone marrow adipose tissue using magnetic resonance imaging and proton density fat fraction (PDFF) may enhance clinical fractures prediction in postmenopausal women.

Objective: This study aimed to assess the association between PDFF measurements and clinical fracture incidence.

Methods: A longitudinal study was conducted.

Differences in Pelvic Muscular Shape and Thickness in Women With and Without Significant Bladder Descent.

Introduction And Hypothesis: Pelvic organ prolapse (POP) is the descent of pelvic organs, causing patient discomfort. Despite its increasing prevalence, agreement in the field as to the cause is elusive. Weakness in pelvic floor muscles is implicated, but specific structural changes remain unclear.

Building capacity and capability for science diplomacy: challenges in decolonizing the curriculum for Global Health System Leadership.

Education policy is the front and center of contemporary science diplomacy. This is particularly the case in global health where nation-states are being called upon to equip their health workforce with leadership skills and competencies to improve population health and engage in health system development. In the perspective that follows, we argue that successfully meeting such demands requires not only a high-quality education offering but also one that is aware of and engaged with the coloniality underpinning its underlying assumptions.

An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma.

Background & Objective: While there are fast advances in the detection and management of bladder carcinoma, the number of deaths remains high. Therefore, the identification of an effective biomarker predicting tumor progression in cancer bladder patients is a crucial issue. This study aimed to identify TIPE2 and CD36 expressions in cancer bladder and examine their relationship with clinicopathological data and prognosis.

Predicting Adverse Perinatal Outcomes in Dichorionic Twin Pregnancies: A Multicentre Cohort Study.

Objective: Dichorionic twin pregnancies are associated with increased risks of stillbirth or medically indicated early preterm birth (ePTB) to avoid stillbirths. This study evaluated the predictive value of fetal estimated weight (EFW) and Doppler indices before adverse perinatal outcomes.

Design: Retrospective multicentre cohort study.

The effectiveness of high-flow nasal cannula therapy in comparison with continuous positive airway pressure therapy in patients with obstructive sleep apnea: an open-label randomized crossover trial.

Study Objectives: Continuous positive airway pressure (CPAP) is the most effective treatment for obstructive sleep apnea (OSA). However, its effectiveness is limited by poor long-term compliance. Few recent studies have investigated the effectiveness of high-flow nasal cannula (HFNC) in treating OSA; however, its role remains uncertain.

Antioxidant efficiency of Sarcophyton crude extract against gentamicin toxicity in male albino rats.

Gentamicin is an antibiotic widely used in treating bacterial infections. However, it's clinical interest is limited by it's toxic side effects on vital organs. Sarcophyton soft coral is a source of natural products with a range of bioactivities.

Characteristics and Outcomes of Heart Failure Outpatients with Improvement in Ejection Fraction in Qatar.

Introduction: Heart failure with reduced ejection fraction (HFrEF) in Qatar has not been well characterized in the outpatient setting.

Objective: To describe the characteristics of patients with HFrEF who had improvement in their left ventricular ejection fraction (LVEF) and independent predictors of improvement.

Methods: This retrospective cohort study conducted at the advanced heart failure (HF) clinic in Qatar recruited patients who visited the clinic between January 2017 and December 2018.

Diagnostic and epidemiological landscape of anaerobic bacteria in Europe, 2020-2023 (ANAEuROBE).

Introduction: Despite being implicated in a wide spectrum of community- and healthcare-acquired infections, anaerobes have not yet been incorporated into systematic surveillance programs in Europe.

Methods: We conducted a multicentre retrospective observational study analysing all anaerobic strains isolated from blood cultures in 44 European Hospital Centres over a 4-year period (2020-2023). Diagnostic approach, epidemiology, and antimicrobial susceptibility according to EUCAST v.

Portable ultra-low-field magnetic resonance imaging enables postictal seizure imaging.

The detection of transient peri-ictal magnetic resonance imaging (MRI) abnormalities has been variable after epileptic seizures. The most common reason for this variability is that abnormalities may disappear if the interval between seizure and scan acquisition is prolonged using conventional high-field systems. Here, we deployed a portable ultra-low-field MRI system in the presurgical evaluation at the bedside of individuals with epilepsy.

Hierarchically Porous Anatase Nanoparticles Derived from One-Dimensional Lepidocrocite Titanate for Bisphenol-A Photodegradation.

Herein, we discuss the conversion of one-dimensional lepidocrocite (1DL) titanate nanofilaments to anatase. Upon heating at temperatures >400 °C, the hierarchical 1DLs porous mesostructured particles transform to anatase, while retaining their morphology. These assemblies are characterized via X-ray diffraction, scanning and transmission electron microscopy, Fourier transform infrared spectroscopy, and solid-state ultraviolet absorbance.

Rethinking Risk in Hypertrophic Cardiomyopathy: Assessing the Role of Myocardial Fibrosis and Left Ventricular Hypertrophy in Sudden Cardiac Death.

The American College of Cardiology/American Heart Association guidelines recommend implantable cardioverter-defibrillator (ICD) implantation for patients with hypertrophic cardiomyopathy (HCM) with a wall thickness of ≥30 mm (class IIA), whereas they give a class IIB recommendation for the implantation of an ICD on the basis of extensive late gadolinium enhancement alone. In this analysis, we show that in a high-risk population with ICD implanted for primary prevention of sudden cardiac death (SCD) in the setting of HCM, the presence of massive left ventricular hypertrophy predicts a higher incidence of ICD therapy than other traditional SCD risk factors. The presence of extensive myocardial fibrosis, however, identifies a subgroup of patients without massive left ventricular hypertrophy who have an equally high incidence of receiving appropriate device therapy.

The association of bisphosphonates, calcium levels and PTH levels with bioprosthetic aortic valve degeneration.

Background: Bioprosthetic aortic valve (bAV) degeneration represents a major concern following aortic valve replacement (AVR). The association of bisphosphonates, serum calcium and serum parathyroid hormone (PTH) with native AV degeneration have been studied extensively. However, their association with structural valve degeneration (SVD) is yet to be elucidated.

Colloidal Stability, Sedimentation, and Aggregation of Crystalline Two-Dimensional Crumpled Birnessite Flakes, Their Dye Adsorption and Immune Cell Response.

Highly crystalline two-dimensional (2D) flakes of birnessite, a polymorph of manganese oxide with a MnO chemistry, were synthesized by reacting manganese oxide, MnO, at 80 °C with aqueous solutions of tetramethylammonium hydroxide (TMAH) for tens of hours. Their colloidal stability, aggregation, and sedimentation were studied as a function of ionic strengths of Na and Li cations. After reaction, a water-based stable colloidal suspension (ζ-potential ∼ -31 ± 1 mV) was obtained.

Stable Yet Destabilised: Towards Understanding Brain Network Dynamics in Psychogenic Disorders.

Psychogenic non-epileptic seizures (PNES) are seizure-like episodes that resemble behavioral aspects observed for epileptic seizures but are without the abnormal electrical activity typically seen in epilepsy. The lack of an etiologic model for PNES as well as limitations of available diagnostic methods largely hinders a clear-cut distinction from epilepsy and from a normal functioning brain. In this study, we investigate the brain dynamics of people with PNES and people with epilepsy during phases far-off seizures and seizure-like events as well as the brain dynamics of a control group.

Multilevel barriers and supportive care preferences of metastatic breast cancer patients and their caregivers: a mixed-methods analysis.

Purpose: The diagnosis of metastatic breast cancer (MBC) marks a transition from curative to palliative care, bringing significant psychosocial challenges, often exacerbated by racial and ethnic disparities. This mixed-methods study, grounded in the socioecological model, sought to examine distress levels among MBC patients and caregivers across academic and safety-net healthcare settings and to explore how individual, interpersonal, and system-level factors-shaped by intersecting identities such as race/ethnicity and socioeconomic status-influence unmet supportive care needs and intervention preferences.

Methods: Surveys and interviews were conducted with a racially and ethnically diverse group of MBC patients (N = 27) and caregivers (N = 19), recruited from a comprehensive cancer center with academic practice and safety-net hospital affiliates.

Cochlear implantation at King Abdallah Medical City, Makkah, Saudi Arabia: Single institution experience, a 5-years retrospective analysis.

Objectives: To review the outcomes of the cochlear implantation program at King Abdallah Medical Center (KAMC) in Makkah from its launch in 2018 to 2023, focusing on patient demographics, procedural details, and complications.

Methods: A retrospective analysis was conducted on 133 patients who underwent cochlear implantation (CI) at KAMC between May 2018 and June 2023. Data collected included demographics, hearing loss types, anatomical findings from imaging, types of CI devices, procedural challenges, and complications.

Prevalence of adherence and its impact on quality of life in oral anticoagulant users in Egypt: A cross-sectional study from two Egyptian university hospitals.

Background: Oral anticoagulant therapy (OAT) is critical for managing thromboembolic disorders, but adherence challenges significantly impact its effectiveness and patients' quality of life (QoL). This study explores the predictors of adherence and their effects on QoL among OAT users in Egypt.

Methods: This multi-center cross-sectional descriptive study with an analytical component was conducted at Mansoura University Hospital and Ain Shams University Hospital.

Effect of surface conditioning on the adhesive bond strength of 3D-printed resins used in permanent fixed dental prostheses.

Objectives: Although pre-treatment parameters for subtractive computer-aided design/computer-aided manufacturing (CAD/CAM) materials have been thoroughly investigated, data regarding additive restorative materials designed for permanent use in the oral cavity are scarce. This study investigated the effects of abrasive materials and blasting pressure on the bond strength of 3D-printed resins used in permanent restorations.

Methods: A total of n = 44 test specimens additively manufactured from Formlabs' `Permanent Crown Resin' were prepared.

Elevated Lipoprotein(a) Levels Linked to New-Onset Atrial Fibrillation: Insights from a Retrospective Cohort Study.

Aims: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Although lipoprotein(a) [Lp(a)] is known to be a well-established risk factor for atherosclerotic cardiovascular disease (ASCVD), its role in development of AF, independent of this association, remains unclear.

Methods: Adult patients from the three Mayo Clinic sites with a baseline Lp(a) and without AF history were included.

Analysis of ILD-RADS reproducibility and validity: Can different degrees of experience affect the interpretation?

Purpose: To evaluate the reliability, validity and applicability of ILD-RADS among readers with different levels of experience.

Methods: This prospective tri-center study included 159 patients with clinically diagnosed ILD who underwent high-resolution CT (HRCT). Two experienced thoracic radiologists, two general radiologists, and one pulmonologist independently evaluated the HRCT images blinded to the patient's clinical data and assigned ILD-RADS category for each patient.

Design, Synthesis, and Molecular Docking Studies of Indolo[3,2-c]Quinolines as Topoisomerase Inhibitors.

Background: The tetracyclic indoloquinoline ring system has attracted considerable interest in the recent past due to its broad spectrum of biological activities and its binding to various types of nucleic acids.

Objective: This study aims to elucidate their interactions with DNA and their effects on topoisomerases (TOPO) I and II.

Methods: Several compounds derived from 6-amino-11H-indolo[3,2-c]quinoline with diverse groups on the quinoline ring have been successfully synthesized according to a previously established protocol where all the synthesized indolo[3,2-c]quinoline derivatives were evaluated in vitro against A549, HCT-116, BALB/3T3, and MV4-11 cell lines using MTT (3-[4,5- dimethylthiazol-2-yl]-2,5-diphenyl- tetrazolium bromide) assay.