Investigation of and gene polymorphisms and their association with susceptibility to colorectal cancer.

Background: This study investigates the association of single nucleotide polymorphism in glutathione S transferase P1 (rs1695 and rs1138272) and phosphatase and TENsin homolog (rs701848 and rs2735343) with the risk of colorectal cancer (CRC).

Patients And Methods: In this case-control study, 250 healthy controls and 200 CRC patients were enrolled. All subjects were divided into 3 groups: healthy control, patients, and overall (control + patients).

Significance of additives to enhance the acceptance of poison bait in poultry rodents of Haripur, Khyber Pakhtunkhwa, Pakistan.

Rodent infestation on poultry farms incurs heavy economic losses to this industry by causing feed loss and disease introduction. Development and continuous improvement of rodents control techniques are vital to minimize and control the damages caused by rodents. Here, we test the feed preference of rodents for locally available and palatable food grains viz.

Metabolite profiling and biochemical investigation of the antidiabetic potential of Loranthus pulverulentus Wall n-butanol fraction in diabetic animal models.

Ethnopharmacological Relevance: Globally, 537 million individuals are estimated to have diabetes. The traditional use of herbs for ameliorating diabetes symptoms is a common practice in Pakistan and use of Loranthus pulverulentus Wall (L. pulverulentus) by local people in Azad Jammu and Kashmir has been reported.

Enhanced Expression of RAGE AXIS Is Associated with Severity of COVID-19 in Patients with Comorbidities.

There is a limited understanding of molecular and cellular events that derive disease progression in patients with corona virus disease 2019 (COVID-19). Receptor for advanced glycation end products (RAGE) is hyperactive in development and complications of several diseases by mediating oxidative stress and inflammation in the body. The present study aims to explore activation of RAGE signaling in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with preexisting comorbidities, including hypertension and or diabetes.

Anatomical Variations in Pulmonary Fissures on Computed Tomography (CT).

Objective To determine the frequency of anatomical variations in lung fissures using computed tomography (CT) at a tertiary care hospital in Karachi, Pakistan. Methods A cross-sectional study was conducted in the department of Radiology and Imaging Services at Memon Medical Institute Hospital, Karachi, between November 2021 to April 2022. Patients aged between 15 to 92 years with a completed high-resolution CT scan chest were included.

Cloning, purification, structural, and functional characterization of methicillin-resistant Staphylococcus aureus (MRSA252) RsbV protein.

Drug resistance bacteria produce various proteins to combat xenobiotic, physical, and environmental stresses. These proteins play a pivotal role in bacterial cell survival, and thus are the focus of extensive research as potential targets for anti-bacterial drug discovery. During the current study, the MRSA252 (Methicillin-resistant Staphylococcus aureus) anti-σ factor antagonist (RsbV) protein was expressed to study its structure, and function in vitro.