Publications by authors named "Durmaz L"

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  • Baicalin is a common flavonoid found in various herbal preparations, particularly in Eastern medicine, and has been studied for its properties as an antioxidant, antidiabetic, anticholinergic, and antiglaucoma agent.
  • The research involved multiple antioxidant testing methods, and baicalin hydrate showed a DPPH radical scavenging IC value of 13.40 μg/mL, which is competitive with other reference antioxidants such as BHA and Trolox.
  • Additionally, baicalin hydrate was evaluated for its ability to inhibit key enzymes linked to serious conditions like Alzheimer's disease, glaucoma, and diabetes, demonstrating effective inhibition against acetylcholinesterase, butyrylcholinesterase, carbonic
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  • Onion is rich in dietary components like phenolics and flavonoids, with spiraeoside being a notable flavonoid investigated for its antioxidant properties.
  • Various antioxidant techniques revealed spiraeoside's effectiveness in scavenging radicals, showing results similar to BHT but less potent than standard antioxidants like α-tocopherol and trolox.
  • Additionally, spiraeoside demonstrated significant inhibitory effects on metabolic enzymes linked to diseases such as Alzheimer's, diabetes, and glaucoma, indicating its potential as a therapeutic agent.
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Background: We were able to demonstrate the feasibility of a new robotic system (Versius, CMR Surgical, Cambridge, UK) for procedures in small inanimate cavities. The aim of this consecutive study was to test the Versius system for its feasibility, performance, and safety of robotic abdominal and thoracic surgery in piglets simulating infants with a body weight lower than 10 kg.

Methods: A total of 24 procedures (from explorative laparoscopy to thoracoscopic esophageal repair) were performed in 4 piglets with a mean age of 12 days and a mean body weight of 6.

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  • Magnofluorine, a plant-derived secondary metabolite, demonstrates significant antioxidant activity through various bioanalytical assays, outperforming some common synthetic antioxidants.
  • The compound exhibits inhibition effects on key metabolic enzymes associated with diseases like diabetes and Alzheimer's, suggesting potential therapeutic applications.
  • Molecular docking studies indicate Magnofluorine's interactions with these enzymes, highlighting its promise for future industrial and medicinal use.
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Background: The aim of this review is to discuss experimental and clinical techniques and interventions of fetal surgery which have been performed minimally invasively by the means of a three-port approach for the fetoscope and instruments for the left and right hand of the surgeon (bimanual minimally invasive fetal surgery).

Methods: a print and electronic literature search was performed; the titles and abstracts were screened and included reports were reviewed in a two-step approach. First, reports other than minimally invasive fetal surgery were excluded, then a full text review and analysis of the reported data was performed.

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  • Coumestrol is a phytoestrogen and polyphenolic compound known for its presence in various plants, and this study explores its potential health benefits, including antioxidant properties and effects on metabolic enzymes linked to diseases like Alzheimer's and diabetes.
  • The study employed different antioxidant activity assays such as DPPH, ABTS, and others, comparing Coumestrol’s effectiveness to established antioxidants like BHA and Trolox, showing a strong ability to scavenge free radicals.
  • Coumestrol also demonstrated significant inhibitory effects on important metabolic enzymes related to Alzheimer's, glaucoma, and diabetes, indicating its potential therapeutic applications in these conditions.
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(1) Background: The morbidity of gastroschisis is defined by exposure of unprotected intestines to the amniotic fluid leading to inflammatory damage and consecutive intestinal dysmotility, the viscero-abdominal disproportion which results in an abdomen too small to incorporate the herniated and often swollen intestine, and by associated pathologies, such as in complex gastroschisis. To prevent intestinal damage and to provide for growth of the abdominal cavity, fetal interventions such as amnio exchange, gastroschisis repair or covering have been evaluated in several animal models and human trials. This review aims to evaluate the reported techniques for the fetal treatment of gastroschisis by focusing on minimally invasive procedures.

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In order to evaluate the antioxidant activity of evaporated ethanolic extract (EESB) and lyophilized water extract (WESB) of Shaggy bindweed ( Mill. Subs), some putative antioxidant methods such as DPPH· scavenging activity, ABTS scavenging effect, ferric ions (Fe) reduction method, cupric ions (Cu) reducing capacity, and ferrous ions (Fe) binding activities were separately performed. Also, ascorbic acid, α-tocopherol and BHT were used as the standard compounds.

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Kınkor () is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on the biological activities and chemical composition of this medicinal plant. In this study, the phytochemical composition; some metabolic enzyme inhibition; and antidiabetic, anticholinergic, and antioxidant activities of this plant were assessed.

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Pain, as a sensible alarm signal of living organisms to avoid tissue damage, is a common and debilitating consequence of a lot of disorders and diseases. The management of chronic pain is particularly challenging. For pain treatment, many analgesic drugs are used for their therapeutic effects.

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  • The study examined the phenolic content and various biological activities of four Gypsophila species, revealing that methanol extracts had higher phenolic levels and antioxidant properties than water extracts.
  • All species showed dose-dependent antiproliferative effects on cancer cell lines and significant inhibition of enzymes related to diabetes and neurodegenerative diseases.
  • The findings suggest Gypsophila taxa have promising potential for pharmaceutical applications, especially in developing drugs for cancer, diabetes, and cognitive health.
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  • Aldose reductase (AR), α-amylase, and α-glycosidase are crucial enzymes to manage diabetic complications, and AR was successfully purified from sheep kidney.
  • Phenolic compounds were tested for their inhibitory effects on these enzymes, with findings showing varying effectiveness across different compounds.
  • Genistein was most effective against AR and α-glycosidase, while delphinidin chloride was most effective against α-amylase, suggesting potential for these compounds in preventing or treating diabetes-related issues.
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  • A new synthetic method using trifluoroacetic acid allows the creation of a specific compound involving phenylthiourea, salicylaldehyde, and methyl-3-oxobutanoate.
  • The resulting N-substituted tetrahydropyrimidines are found to effectively inhibit key enzymes including acetylcholinesterase and human carbonic anhydrase isoforms, with low inhibition values indicating strong potency.
  • Additionally, these compounds have been shown to possess significant antioxidant activity, evaluated through various in vitro assays.
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Cynarin is a derivative of hydroxycinnamic acid and it has biologically active functional groups constituent of some plants and food. We elucidated the antioxidant activity of cynarin by using different in vitro condition bioanalytical antioxidant assays like DMPD(•+), ABTS(•+), O2(•-), DPPH(•) and H2O2 scavenging effects, the total antioxidant influence, reducing capabilities, Fe(2+) chelating and anticholinergic activities. Cynarin demonstrated 87.

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Subcutaneous emphysema is the condition in which air or other gases penetrate the skin and submucosa causing soft-tissue distention. This type of emphysema may be traumatic, iatrogenic or may occur spontaneously. This report describes the youngest case of subcutaneous emphysema related to dental treatment that has been documented to date.

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Introduction: Living-donor renal transplantation has become common worldwide. However, living-donor nephrectomy is not a complication-free procedure. This retrospective study reviews the intra-and postoperative risks and complications of donor nephrectomies at our institution between 1994 and 2002.

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