A Ray of Hope in Darkness: A Case Report on the Rehabilitation of a Patient With Sudden Visual Impairment Due to Traumatic Optic Neuropathy.

Traumatic optic neuropathy (TON) refers to optic nerve damage resulting from trauma to the eye or head. Loss of visual functions is the hallmark of all optic neuropathies. Due to the sudden loss of vision, even after treatment, patients feel physically and psychologically disturbed.

Simultaneous screening for antibodies to myelin oligodendrocyte glycoprotein and aquaporin-4 in patients with optic neuritis using cell-based assay.

This study was aimed to test simultaneous detection of antibodies to myelin oligodendrocyte glycoprotein (MOG)/aquaporin4 AQP4) in serum samples of patients with clinically-diagnosed optic neuritis (ON), by fixed cell-based immunofluorescence assay (CBIFA). The study involved 237 serum samples of patients with ON which were tested for MOG and AQP4 antibodies using fixed CBIFA kit which utilizes AQP4 or MOG protein transfected cells as a substrate. Of 237 serum samples, 22 (9%) were positive for AQP4, 66 (28%) were positive for MOG, and 138 (58%) were negative for both AQP4 and MOG antibodies.