Publications by authors named "Dureali Mirjat"
Article Synopsis
- The study aimed to understand the genetic factors of prostate cancer by analyzing 14 genes linked to cancer susceptibility using Next Generation Sequencing (NGS).
- Key findings revealed pathogenic mutations in genes like BRCA1, BRCA2, and TP53, along with benign variations, highlighting their differing roles in cancer progression.
- Functional tests showed that mutations in BRCA1 and BRCA2 were linked to lower expression levels and increased sensitivity to certain chemotherapy drugs, while mutations in TP53 did not notably affect drug response.
Background The neurological condition known as multiple sclerosis (MS) is crippling and has a complicated pathogenesis as well as a wide range of clinical symptoms, including fatigue, difficulty walking, numbness or tingling, muscle spasms and spasticity, weakness, vision problems, dizziness and vertigo, bladder and bowel dysfunction, cognitive impairment, and emotional changes. The complete scope of MS pathology cannot be fully captured by conventional magnetic resonance imaging (MRI) sequences, which has led to the investigation of sophisticated MRI methods for better diagnosis and treatment. Objective This study aims to evaluate the clinical relevance of advanced MRI sequences in multiple sclerosis.
View Article and Find Full Text PDFTWIST1 is a transcription factor that is necessary for healthy neural crest migration, mesoderm development, and gastrulation. It functions as a key regulator of epithelial-to-mesenchymal transition (EMT), a process by which cells lose their polarity and gain the ability to migrate. EMT is often reactivated in cancers, where it is strongly associated with tumor cell invasion and metastasis.
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