Publications by authors named "Durante-Mangoni E"

Background And Aim: Ceftobiprole, an advanced-generation cephalosporin with broad bactericidal activity, is approved for community-acquired and hospital-acquired pneumonia (excluding ventilator-associated pneumonia). We aimed to evaluate, in a real-world setting, the safety profile of ceftobiprole in patients with risk conditions (severe renal impairment, hepatic impairment, and immunocompromised status), groups excluded from clinical trials.

Methods: In this retrospective study (NCT04170309), 396 consecutive charts of patients treated with ceftobiprole during 2016-2022 in 15 centres in France, Italy, and Spain were analysed: 62 had severe renal impairment, 51 had a hepatic impairment, 120 were immunocompromised, and 203 had no predefined risk condition (controls).

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Purpose: Infective endocarditis (IE) is a heterogeneous disease undergoing epidemiological changes. Whether those changes have an impact on the correlates of embolic events (EE) remains unclear. We analyzed the correlates of EE and proposed a diagnostic score model in a large contemporary cohort.

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  • The text indicates that clinical insights do not need additional requirements or prerequisites for understanding.
  • It suggests that the information provided is straightforward and accessible.
  • This implies that anyone can grasp the essential concepts without needing specialized knowledge.
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The AIDA randomized clinical trial found no significant difference in clinical failure or survival between colistin monotherapy and colistin-meropenem combination therapy in carbapenem-resistant Gram-negative infections. The aim of this reverse translational study was to integrate all individual preclinical and clinical pharmacokinetic-pharmacodynamic (PKPD) data from the AIDA trial in a pharmacometric framework to explore whether individualized predictions of bacterial burden were associated with the trial outcomes. The compiled dataset included for each of the 207 patients was (i) information on the infecting Acinetobacter baumannii isolate (minimum inhibitory concentration, checkerboard assay data, and fitness in a murine model), (ii) colistin plasma concentrations and colistin and meropenem dosing history, and (iii) disease scores and demographics.

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A growing number of probiotic-containing products are on the market, and their use is increasing. Probiotics are thought to support the health of the gut microbiota, which in turn might prevent or delay the onset of gastrointestinal tract disorders. Obesity, type 2 diabetes, autism, osteoporosis, and some immunological illnesses are among the conditions that have been shown to possibly benefit from probiotics.

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Article Synopsis
  • - The 2023 Duke-ISCVID criteria were developed to enhance the classification of infective endocarditis (IE) for better research and clinical outcomes, requiring further external validation.
  • - A study at Amsterdam University Medical Center reviewed 595 patients with suspected IE, finding that the new criteria were more sensitive and specific compared to earlier criteria, highlighting their effectiveness in diagnosis.
  • - Overall, the new criteria showed significant improvements in diagnostic accuracy, particularly due to changes in major microbiological and imaging requirements, marking a notable advancement in how suspected IE cases are classified.
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The spread of multidrug-resistant Gram-negative bacterial infections is a significant issue for worldwide public health. Gram-negative organisms regularly develop resistance to antibiotics, especially to β-lactam antimicrobials, which can drastically restrict the number of therapies. A third-generation cephalosporin and the non-β-lactam β-lactamase inhibitor avibactam, which exhibits broad-spectrum β-lactamase inhibition , are combined to form ceftazidime-avibactam (CAZ-AVI).

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(1) Background: Leadless pacemakers (LPs) have been proposed as a reimplantation strategy in pacing-dependent patients undergoing cardiac implantable electronic device (CIED) extraction for infection. In this study, we analysed the risk of LP infection when this device is implanted before lead extraction. (2) Methods: This was a retrospective study including patients who underwent LP implantation between 2017 and 2022.

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  • Carbapenem-resistant Acinetobacter baumannii (CRAB) infections pose a serious treatment challenge due to limited options, but new drugs like cefiderocol and sulbactam-durlobactam offer hope.
  • The review evaluates how these drugs work, their resistance mechanisms, and their effectiveness against CRAB, showing they both show excellent antimicrobial activity.
  • Cefiderocol has comparable efficacy to existing treatments like colistin, with fewer safety concerns, while sulbactam-durlobactam appears particularly useful for critically ill patients when other antibiotics fail.
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  • The study examined the short- and long-term mortality rates of infective endocarditis (IE) among people who inject drugs (PWID) by analyzing data from hospitalized patients between 2000 and 2021.
  • Out of 485 IE patients, 55 (11%) were PWID, who were matched with 55 non-intravenous drug users (N-IDU) based on age and sex; PWID had higher rates of HCV co-infection and advanced liver disease.
  • Findings indicated that PWID faced a nearly threefold increased risk of long-term mortality after being hospitalized for IE compared to the N-IDU group, highlighting the need for further investigation into the factors contributing to their elevated mortality risk
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Background And Aim: Infective endocarditis (IE) is a complex thrombo-inflammatory disorder, the pathogenesis of which involves a multifaceted interplay between vascular damage and bacterial virulence factors. This study aimed to assess the prognostic role of small dense low-density lipoprotein (sdLDL) cholesterol in patients with IE and its correlation with various disease-related features.

Methods: A cohort of 198 patients with definite IE was included in this study.

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Disseminated intravascular coagulation (DIC) is a recurrent complication of sepsis. Since DIC not only promotes organ dysfunction but also represents a strong prognostic factor, it is important to diagnose DIC as early as possible. When coagulation is activated, fibrinolysis is inhibited, blood thinners are consumed, and a condition is created that promotes blood clotting, making it more difficult for the body to remove fibrin or prevent it from being deposited in the blood vessels.

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Sepsis is a major global health problem that results from a dysregulated and uncontrolled host response to infection, causing organ failure. Despite effective anti-infective therapy and supportive treatments, the mortality rate of sepsis remains high. Approximately 30-80% of patients with sepsis may develop disseminated intravascular coagulation (DIC), which can double the mortality rate.

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About 40% of the Guillain-Barré syndrome (GBS) cases are associated with prodromal infections; occasionally, it has been associated to chronic hepatitis C or its reactivation. A 38-year-old man came to our attention after transaminase elevation occurred during recovery from GBS. All the possible causes of acute hepatitis were excluded except for the positivity of HCVRNA, and a diagnosis of new onset hepatitis C was made.

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  • The study compares infective endocarditis (IE) outcomes in patients after surgical aortic valve replacement (SAVR) versus transcatheter aortic valve replacement (TAVR), aiming to identify differences in clinical presentation, microbiological profiles, management, and outcomes.
  • Data was gathered from two international registries, focusing on patients with IE affecting aortic valve prostheses, and included a matched comparison of TAVR and SAVR patients.
  • The findings revealed that patients with surgical bioprostheses had higher rates of complications but similar one-year mortality rates compared to those with TAVR, indicating important differences in infection characteristics and treatment but comparable long-term outcomes.
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Background: Pneumonia and bloodstream infections (BSI) due to extensively drug-resistant (XDR) , XDR , and carbapenem-resistant Enterobacterales (CRE) are associated with high mortality rates, and therapeutic options remain limited. This trial assessed whether combination therapy with colistin and meropenem was superior to colistin monotherapy for the treatment of these infections.

Methods: The OVERCOME (Colistin Monotherapy versus Combination Therapy) trial was an international, randomized, double-blind, placebo-controlled trial.

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  • A systematic review was conducted to assess the clinical characteristics and outcomes of patients with MitraClip-related infective endocarditis (IE), a condition linked to newer cardiac devices perceived to have lower infection risks.
  • The review included data from various medical databases and covered 26 cases, revealing that most patients were elderly, with a median age of 76 years, and significantly suffering from heart failure symptoms and presence of Staphylococcus aureus as the primary infection cause.
  • The findings indicated a concerning in-hospital mortality rate of 50%, regardless of whether patients received surgical treatment or managed conservatively, highlighting the need for clinicians to recognize the risks posed by MitraClip-related infections.
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Background: No clear evidence supports the use of cefiderocol as first line treatment in A. baumannii infections.

Methods: We conducted an observational retrospective/prospective multicenter study including all patients> 18 years with carbapenem-resistant A.

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Introduction: Ceftaroline and ceftobiprole show activity against resistant Gram-positive cocci as well as good tolerability and are increasingly used in diverse infections. No comparative data on the efficacy and safety of ceftaroline and ceftobiprole in real-life are available.

Methods: In this single-centre, observational, retrospective clinical study, the outcomes of patients treated with ceftaroline or ceftobiprole in our hospital were compared, assessing clinical data, use and drug exposure of study antibiotics, and outcomes.

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