Publications by authors named "Duraivadivel Prabakaran"
β-lactam resistance in bacteria is primarily mediated through the production of β-lactamases. Among the several strategies explored to mitigate the issue of β-lactam resistance, the use of plant secondary metabolites in combination with existing β-lactams seem promising. The present study aims to identify possible β-lactam potentiating plant secondary metabolites following and approaches.
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- Extensive research has highlighted the antibacterial properties of essential oil (EO) metabolites from a specific rhizome against multi-drug-resistant bacteria, including through molecular interactions with the target enzyme TyrRS.
- The study conducted molecular docking on various EO metabolites, showing that compounds like mustakone and khusinol have binding affinities comparable to the standard drug chloramphenicol, despite most metabolites lacking hydrogen bonding interactions.
- Findings from molecular dynamics simulations support the potential of mustakone and khusinol as promising candidates for developing new antibacterial drugs due to their stability and advantageous pharmacokinetic properties.
Development of antibiotic resistance (ABR) in bacteria and its multidimensional spread is an emerging global threat that needs immediate attention. Extensive antibiotics (AB) usage results in development of ABR in bacteria by target modification, production of AB degrading enzymes, porin modifications, efflux pumps overexpression, etc. To counter this, apart from strict regulation of AB use and behavioural changes, research and development (R&D) of newer antimicrobials are in place.
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