Pristine B fullerene as a potential gemcitabine drug carrier for anti-lung cancer properties: a DFT and QTAIM study.

Novel biomedical applications of various nanomaterials are being extensively researched as drug delivery systems. These nanomaterials deliver various anticancer treatments into the specific tumor cell sites, which reduces their terrible side effects. In this study, we have used DFT/B3LYP/6-311++G(d,p) level of theory to examine the efficacy of the pristine B fullerene (Boron) as a drug delivery vehicle for gemcitabine an anti-lung cancer medication at various position.

Differential phagocytic expression of IC-21 macrophages and their scavenging receptors during inflammatory induction by oxysterol: A microscopic approach.

Phagocytosis by macrophages dates back to a long history in science, this present study deals with new approaches that have been analyzed and standardized towards the interesting aspects of primary and secondary macrophages. The distinct morphological differences in primary and secondary phagocytic cells were observed and the phagocytic response of secondary macrophages under the influence of 7-ketocholesterol and lipopolysaccharide was analyzed. The primary peritoneal and secondary IC-21 cells unveiled explicit differences in nuclear numbers shapes and sizes of the granules present within the cytoplasmic region.

Exploring nonlinearity in quarter car models with an experimental approach to formulating fractional order form and its dynamic analysis.

This study explores the inherent nonlinearity of quarter car models by employing an experimental and numerical approach. The dynamics of vehicular suspension systems are pivotal for ensuring passenger comfort, vehicle stability, and overall ride quality. In this paper we assessed the impact of various parameters and components on suspension performance, enabled the optimization of ride comfort, stability, and handling characteristics.

Phytol from prevents NF-κB-mediated inflammatory responses during macrophage polarization.

Unlabelled: Macrophages are primary immune cells that mediate a wide range of inflammatory diseases through their polarization potential. In this study, phytol isolated from has been explored against 7-ketocholesterol and bacterial lipopolysaccharide-induced macrophage polarization in IC-21 cells. Isolated phytol has been characterized using GC-MS, TLC, HPTLC, FTIR, H-NMR, and HPLC analyses.

Enhanced hydrogen storage of alkaline earth metal-decorated B (n = 3-14) nanoclusters: a DFT study.

Context: Boron-based nanostructures hold significant promise for revolutionizing hydrogen storage technologies due to their exceptional properties and potential in efficiently accommodating and interacting with hydrogen molecules. In this paper, boron-based B (n = 3-14) nanoclusters decorated with alkaline earth metals (AEM = Ca and Be) were investigated for hydrogen storage applications based on density function theory (DFT) calculations. To evaluate H adsorption capability, the adsorption energies, frontier molecular orbitals (FMOs), natural bond orbital (NBO), and quantum theory of atoms in molecule (QTAIM) analysis are performed.

The effect of yoga on insomnia and quality of life among nursing professionals during COVID-19: A pre-post-test interventional study.

Background: The coronavirus disease 2019 (COVID-19) pandemic has taken a toll on the well-being and quality of life (QoL) of healthcare professionals, especially nurses. Insomnia, a common consequence of the pandemic, adds to the physical and mental strain on healthcare workers.

Aim: This study aimed to assess the impact of workplace yoga intervention on insomnia severity and QoL among female nursing and healthcare professionals during the pandemic.

Sitosterol-rich against 7-ketocholesterol and lipopolysaccharide-mediated atherogenic responses by modulating NF-ΚB/iNOS signalling pathway in macrophages.

L., commonly known as Tartara, is an edible herb used as traditional medicine in many countries of Africa and Asia. This study aimed to elucidate the effect of a phytosterol-rich extract of on 7-ketocholesterol-mediated atherosclerosis in macrophages.

The impact of extended pulp chamber preparations on the clinical performance of endocrowns in Indian patients: A 1-year observational study.

Purpose: The limitations of foundation restorations have been reduced with the advent of endocrowns. Despite their success, the extent of endocrowns tooth preparation into the pulp chamber has not been fully explored in the literature. The study aimed to evaluate the clinical performance of endocrowns with 5 mm extended pulp chamber tooth preparations in Indian patients over a 1- year period using modified USPHS criteria.

Impact of external excitations on blinking enhanced synchronization in bistable vibrational energy harvesters.

Vibrational energy harvesters are capable of converting low-frequency broad-band mechanical energy into electrical power and can be used in implantable medical devices and wireless sensors. With the use of such energy harvesters, it is feasible to generate continuous power that is more reliable and cost-effective. According to previous findings, the energy harvester can offer rich complex dynamics, one of which is obtaining the synchronization behavior, which is intriguing to achieve desirable power from energy harvesters.

Econometric and stochastic analysis of stock price before and during COVID-19 in India.

Unexpected and sudden spread of the novel Coronavirus disease (COVID-19) has opened up many scopes for researchers in the fields of biotechnology, health care, educational sectors, agriculture, manufacturing, service sectors, marketing, finance, etc. Hence, the researchers are concerned to study, analyze and predict the impact of infection of COVID-19. The COVID-19 pandemic has affected many fields, particularly the stock markets in the financial sector.

Obstacle induced spiral waves in a multilayered Huber-Braun (HB) neuron model.

Various dynamical properties of four-dimensional mammalian cold receptor model have been discussed widely in the literature considering noise and temperature as important parameters of discussion. Though various spiking and bursting behaviors of the neuron under various noise and temperature conditions studied for a single neuron, no much discussions have been done on the collective behavior. We investigate the collective behavior of these temperature dependent stochastic neurons and unlike the neuron models when forced by periodic external force there is no wave reentry or spiral waves in the network.

A Rare Case Report of Primary Hydatid Disease of the Scapula - an Unforeseen Diagnosis!

Introduction: Hydatid disease of the bone is a parasitic infestation in the form of cystic echinococcosis by a tapeworm echinococcus granulosus. Its manifestation in the bone is relatively low and has the ability to mimic other skeletal pathologies.

Case Report: We came across a 30-year-old male farmer with complaints of sero-purulent discharge from a sinus tract wound in the axilla for the past 3 years.

Tofacitinib in the treatment of refractory eczemas - a case series.

Janus Kinase inhibitors have been shown to be effective in the treatment of various dermatoses such as alopecia areata, psoriasis, vitiligo and atopic dermatitis. The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is a common junction for the signaling of several dermatologically significant cytokines and the inhibition of this pathway by JAK inhibitors may be broadly useful in the treatment of various other dermatological disorders. A case series is presented of twelve patients (M:6, F:6) with a mean age 47.

Ribociclib-induced extensive vitiligo-like lesions: possible pathomechanisms with clinical, dermoscopic and histological correlation.

Cyclin dependent kinase (CDK) 4/6 inhibitors are targeted agents which act on cyclin-D and these combined with hormonal therapy have been approved for the treatment of locally advanced or metastatic breast cancer. CDK 4/6 inhibitors have been found to have a tolerable adverse event profile; however, they have been associated with various dermatological adverse events. We report a case of ribociclib-induced vitiligo and discuss the clinical, dermoscopic and histological features with a review of the various possible pathomechanisms involved.

Dipeptidyl peptidase-4 inhibitor-associated cutaneous eruptions: a retrospective observational study.

Background: Dipeptidyl peptidase (DPP)-4 plays a complex role in immune regulation and its inhibition can have effects on the pathogenesis of various skin diseases. Studies have shown that DPP-4 inhibitors are associated with an increased risk of bullous pemphigoid (BP).

Aim: To analyse the clinical and histopathological features of cutaneous adverse events in patients on DPP-4 inhibitors.

Isolation, characterization and degradation performance of oxytetracycline degrading bacterium Planococcus sp. strain pw2.

Oxytetracycline (OTC), is a widely used veterinary antibiotic for treatment and prophylaxis in aquaculture. As an emerging pollutant, OTC in the environment exerts selective pressure on aquatic organisms causing proliferation of antibiotic resistant genes. In the present study, an OTC tolerant isolate labelled as pw2 was selected among the 11 OTC tolerant isolates, isolated from the aquaculture effluent, for investigating its OTC degrading potential.

Spiral waves in a hybrid discrete excitable media with electromagnetic flux coupling.

Though there are many neuron models based on differential equations, the complexity in realizing them into digital circuits is still a challenge. Hence, many new discrete neuron models have been recently proposed, which can be easily implemented in digital circuits. We consider the well-known FitzHugh-Nagumo model and derive the discrete version of the model considering the sigmoid type of recovery variable and electromagnetic flux coupling.

Local and network behavior of bistable vibrational energy harvesters considering periodic and quasiperiodic excitations.

Vibrational energy harvesters can exhibit complex nonlinear behavior when exposed to external excitations. Depending on the number of stable equilibriums, the energy harvesters are defined and analyzed. In this work, we focus on the bistable energy harvester with two energy wells.