[Neuropathological findings in early-onset Alzheimer's disease (E280a-PS1 mutation)].

Introduction And Material: Nine brains belonging to early onset Alzheimer disease (E280A-PS1 mutation) affected individuals from Antioquia, Colombia, were analyzed by neuropathological standard techniques. All individuals were ascertained from genealogies descendents from a common ancestor that shows a dominant autosomical pattern of inheritance.

Results: All cases analyzed were carriers to the E280A-PS1 mutation.