[The toxic and immunomodulating properties of the somatic O-antigen polysaccharide of typhoid bacteria].

In experiments on random bred mice and mice of various strains it was shown that when administered parenterally typhoid bacteria O-somatic antigen polysaccharide possesses the immunomodulatory properties. It stimulates the non-specific resistance of the organism to bacterial infection, produces the polyclonal activation of beta-lymphocytes, possesses the adjuvant properties, activates cells of the mononuclear phagocytic system. At administration in therapeutic doses the drug is not toxic, possesses no carcinogenic, mutagenic and allergenic properties.

[Immunomodulating properties of phospholipids].

Immunomodulating properties of glycerophospholipids were studied. Both phosphatidyl ethanolamines and phosphatidyl cholines exhibited similar immunostimulating effects.

[Immunomodulating properties of salmozan and its effect on the functional activity of macrophages].

The effect of salmozan on the resistance of mice to Listeria monocytogenes infection, the formation of delayed hypersensitivity (DH) to sheep red blood cells in the animals, as well as changes in some functional activity characteristics of macrophages have been studied. The study has revealed that salmozan enhances anti-infectious resistance, suppresses the dermal manifestations of DH, and decreases the level of 5'-nucleotidase in peritoneal macrophages, stimulating their phagocytic activity. The intensity of the drug action depends on the time of its administration.

[Chemical structure and immunostimulating activity of high molecular weight polysaccharides].

An immunostimulating activity of high molecular polysaccharides, dissimilar in their chemical structure, was studied. Inoculation of mice with bacteria of typhoid fever and Kl. pneumoniae demonstrated that O-polysaccharide from typhoid bacteria--multicomponent, branch-chained, phosphorus-containing polysaccharide--exhibited the highest immunostimulating effect.

[Structural similarity and functional activity of molecular fragments of staphylococcal enterotoxin B and thymopoietin II].

Structural similarity between Staphylococcus enterotoxin B and a thymus hormone, thymopoietin, has been revealed concerning thymopentin, one of active centres of thymopoietin. Fragments of enterotoxin B homologous to thymopoietin and their analogues were synthesized their immunological activity studied. Acetyl derivative of the fragment 225-229 of enterotoxin B increased infectional resistance and stimulated delayed type of hypersensitivity reaction.

[Neutral lipids as stimulators of natural unspecific immunity].

Neutral lipids (various monoglycerides and cholesterol derivatives) were used as stimulators of natural unspecific immunity. All the compounds studied exhibited the biological activity. Saturated monoglycerides (chimyl and batyl alcohols) and cholesterol derivatives possessed the highest activity.