Publications by authors named "Dupin C"
Purpose: Since 2021, several reports of Staphylococcus haemolyticus outbreaks in neonatal intensive care units (NICUs) have been reported in France. The aim of this study was to understand how it became established in the NICUs of two facilities, which share the care of newborns.
Methods: All positive S.
Purpose: Nausea is a common symptom in patients irradiated for benign brain tumors. The dorsal vagal complex (DVC) located in the brainstem (BS) has been identified as the center of nausea and vomiting. The objective of our study was to determine an association between mean dose to the DVC and nausea.
View Article and Find Full Text PDFBackground And Aim: Standard rectal cancer treatment includes neoadjuvant radiotherapy sensitized by 5-fluorouracil (5-FU) chemotherapy. However, 5-FU increased chemoradiotherapy response rate comes with significant toxicity, especially in older, frail patients. The development of alternatives to chemotherapy enabling radiosensitization with limited systemic toxicity is therefore needed to improve patient management.
View Article and Find Full Text PDFArticle Synopsis
- * In the experiment, urine was either aspirated from the bladder or leaked through the ureter into the peritoneum of seven minipigs, with samples taken at 4 and 10 hours for analysis of inflammatory response.
- * Results show that while urine in the peritoneum causes bowel distention, there was no significant inflammatory response in the visceral peritoneum within the 10-hour observation period, leading to questions about other mechanisms affecting bowel distention.
Background: Radiation-induced nausea and vomiting have mutiple clinical consequences: delay or refusal of irradiation (decreased antineoplastic efficacy of irradiation), altered quality of life, dehydration, malnutrition, interruption of treatment, decompensation of comorbidities and aspiration. These guidelines aim at defining good clinical practices for management of radiation-induced nausea and vomiting (RINV).
Methods: AFSOS, SFRO, SFH, SFNEP, SFCE and GFRP applied an expert consensus methodology to propose updated guidelines.
Article Synopsis
- Some treatments called biologics can help people with severe asthma and other allergic diseases like skin issues and food allergies.
- Dupilumab has been shown to work well for skin problems and has been approved, while Omalizumab helps with allergies but isn't approved for that use yet.
- There are promising ideas about combining biologic therapy with other treatments for allergies, but more research is needed to confirm if they really work.
Article Synopsis
- Salivary carcinomas of minor salivary glands, particularly in the tongue, are rare tumors that may require surgery and/or (chemo-)radiotherapy for treatment.
- A study involving 103 patients diagnosed between 2009 and 2018 found that the most common types were adenoid cystic and mucoepidermoid carcinomas, with surgery being the primary treatment for most cases.
- Results indicated that 5-year overall survival was 84.7%, while event-free survival was lower at 38.6%; nonsurgical treatment, alcohol use, and tumor location negatively impacted event-free survival, while nodal positivity was a key factor affecting overall survival.
Article Synopsis
- Pulmonary alveolar proteinosis (PAP) is a rare lung syndrome characterized by the accumulation of proteinaceous material, leading to symptoms like progressive dyspnea and hypoxemia, with various diagnostic methods such as CT scans, bronchoalveolar lavage, and genetic testing suggested for evaluation.
- A European Respiratory Society Task Force, comprised of diverse experts, developed evidence-based guidelines for diagnosing and managing PAP using a systematic review of literature and the GRADE approach for assessing the strength of recommendations.
- The Task Force provided specific management recommendations, including whole lung lavage, GM-CSF therapy, and potential treatments like rituximab, alongside diagnostic approaches involving GM-CSF antibody
Article Synopsis
- Locally recurrent nasopharyngeal carcinoma (NPC) poses significant treatment challenges due to the absence of standardized guidelines for postoperative re-irradiation (re-RT).
- This article reviews international recommendations for managing resectable cases of locally recurrent NPC, focusing on re-RT strategies and addressing controversial issues like surgical margins and resectability criteria.
- The consensus suggests a clearer definition of resectability, optimal re-RT doses around 60 Gy, and emphasizes the potential benefits of hyperfractionation to minimize treatment toxicity, aiming to improve patient outcomes.
Purpose: Cranial irradiation can lead to long-term neurological complications, in particular memory disorders. The aim of this prospective study is to evaluate the impact of irradiation of benign skull base tumours located near the hippocampi on autobiographical memory.
Patients And Methods: From 2016 to 2019, patients with cavernous sinus meningioma or pituitary adenoma treated with normofractionated irradiation were included.
Background: Rare cancers constitute less than 10% of head and neck cancers and lack sufficient evidence for standardized care. The French Rare Head and Neck Cancer Expert Network (REFCOR) as established a national database to collect data on these rare cancers. This study aims to describe patient and tumour characteristics in this database.
View Article and Find Full Text PDFBackground: Biological therapies have revolutionized the treatment of severe asthma with type 2 inflammation. Although such treatments are very effective in reducing exacerbation and the dose of oral steroids, little is known about the persistence of symptoms in severe asthma patients treated with biologics.
Purpose: We aim to describe asthma control and healthcare consumption of severe asthma patients treated with biologics.
Background: Predictors of ICU-acquired pulmonary aspergillosis (IPA) are not well-established in critically ill patients with ventilator-associated pneumonia (VAP), making IPA commonly misdiagnosed and anti-fungal therapy delayed. We aimed to develop a clinical score for prediction of IPA among patients with VAP.
Methods: Mechanically ventilated patients who developed VAP in 4 ICUs in Bretagne, Western France, were included.
Objectives: Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive disease requiring multimodal treatment, and multiple new entities once included in the spectrum of SNUC, such as SWI/SNF-deficient carcinomas, are emerging. We aimed to provide new data regarding the role of chemotherapy and surgery and the prognostic factors of disease-free survival.
Methods: This study was based on data from the REFCOR database and included patients with SNUC treated with curative intent from 2007 to 2021 across 22 centres in France.
The Crying Need for a Better Response Assessment in Rectal Cancer.
Curr Treat Options Oncol
November 2023
Since total neoadjuvant treatment achieves almost 30% pathologic complete response, organ preservation has been increasingly debated for good responders after neoadjuvant treatment for patients diagnosed with rectal cancer. Two organ preservation strategies are available: a watch and wait strategy and a local excision strategy including patients with a near clinical complete response. A major issue is the selection of patients according to the initial tumor staging or the response assessment.
View Article and Find Full Text PDFPrevention of ICU-acquired infection with decontamination regimen in immunocompromised patients: a pre/post observational study.
Eur J Clin Microbiol Infect Dis
October 2023
Purpose: Although the proportion of immunocompromised patients admitted to the ICU is increasing, data regarding specific management, including acquired infection (ICU-AI) prophylaxis, in this setting are lacking. We aim to investigate the effect of multiple-site decontamination regimens (MSD) in immunocompromised patients.
Methods: We conducted a prospective pre-/post-observational study in 2 ICUs in Bretagne, western France.
Background: Benralizumab is effective in the treatment of eosinophilic asthma and is being investigated for the treatment of other eosinophil-associated diseases. Reports on the use of benralizumab for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA) are limited to case reports and small case series.
Methods: We conducted a multicentre, retrospective study including EGPA patients treated with off-label benralizumab.
Background: Acinic cell carcinomas (AciCCs) are malignant tumours of the salivary glands. The aim of this work was to analyse data from the national REFCOR multicenter cohort (i) to investigate the prognostic factors influencing survival outcomes in AciCC, (ii) to assess the impact on survival of postoperative radiotherapy (RT) in patients treated for AciCC without high-grade transformation and (iii) to explore the prognostic impact of prophylactic neck dissection (ND) in patients treated for AciCC of the major salivary glands.
Patients And Methods: Data from all the patients treated for salivary AciCC between 2009 and 2020 were extracted from the REFCOR database.