Publications by authors named "Duohao Wang"
Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a rare and aggressive tumor characterized by pathogenic alterations in the fumarate hydratase () gene. Clear cell renal cell carcinoma (clear cell RCC) is a common renal cell carcinoma (RCC) associated with von Hippel-Lindau () gene variations. Here, we reported a case of bilateral RCCs.
View Article and Find Full Text PDFNeuroendocrine differentiation (NED) characterized by the expression of neuroendocrine markers, such as chromogranin A (CgA), is frequently observed in advanced prostate cancer (PCa), the prognostic significance of which is still controversial. Here we specifically addressed the issue of the potential prognostic value of CgA expression in advanced-stage PCa patients with distant metastases and its change over time from metastatic hormone-sensitive (mHSPC) to metastatic castration-resistant prostate cancer (mCRPC). CgA expression was assessed immunohistochemically in initial biopsies of mHSPC, as well as in second biopsies of mCRPC in sixty-eight patients, and its correlation with prognosis (together with conventional clinicopathologic parameters) was analyzed using the Kaplan-Meier method and Cox proportional hazard model.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how brain networks change in patients with left and right cerebellar infarctions, and how these changes relate to cognitive function.
- A total of 37 patients with acute cerebellar infarctions and 27 healthy controls were analyzed using brain imaging and cognitive assessments, revealing that infarctions are associated with significantly lower cognitive test scores compared to controls.
- Results indicated abnormalities in brain network properties for both groups of patients, with specific deficits in processing speed and executive function linked to changes in brain efficiency, particularly in the context of left cerebellar infarction.
Cerebellar lesions can lead to a series of cognitive and emotional disorders by influencing cerebral activity via cerebro-cerebellar loops. To explore changes in cognitive function and structural brain networks in patients with posterior cerebellar infarction, we conducted the current study using diffusion-weighted MRI (32 cerebellar infarction patients, 29 controls). Moreover, a series of neuropsychological tests were used to assess the subject's cognitive performance.
View Article and Find Full Text PDF