Association between the MVK rs2287218 SNP and the risk of coronary heart disease and ischemic stroke: A case-control study.

The association between the mevalonate kinase gene (MVK) single nucleotide polymorphism (SNP) and serum lipid levels has been detected in several previous genome-wide association studies, but the results are inconsistent. In addition, it is still unclear whether the loci indentified exert the similar effect on the susceptibility of coronary heart disease (CHD) or ischemic stroke (IS). Therefore, the present study was undertaken to detect the association between the MVK rs2287218 SNP and serum lipid levels, the susceptibility of CHD and IS in a Southern Chinese Han population.

Association of the rs2929282 polymorphism and serum lipid profiles in two Chinese ethnic groups.

Little is known about the association of the single nucleotide polymorphism (SNP) of rs2929282 near the FERM domain containing 5 () and serum lipid profiles. The present study detected the association of the rs2929282 SNP and several environmental factors with serum lipid profiles in the Han and Jing populations. Genotyping of the rs2929282 SNP in 1065 subjects of Jing and 1061 participants of Han peoples was performed by polymerase chain reaction and restriction fragment length polymorphism, and then confirmed by direct sequencing.

Association of the rs2068888 polymorphism and serum lipid traits in the Chinese Maonan and Han populations.

The cytochrome P450 protein plays an important role in the synthesis of cholesterol and other lipid parameters. But little is known about the association of the single nucleotide polymorphism (SNP) of rs2068888 near cytochrome P450 26A1 gene () and serum lipid profiles in the Chinese Maonan and Han populations. This study explored such association in the two populations.