Development and validation of a risk score for detecting non-alcoholic fatty liver disease.

The development of an easy-to-use noninvasive model to screen nonalcoholic fatty liver disease (NAFLD) is warranted. This study aimed to develop and validate a simple noninvasive NAFLD risk score (NARS). We used the National Health and Nutrition Examination Survey 2017 to March 2020 cycle data.

Effects of different exercise modalities on pediatric and adolescent populations with developmental disorders: a network meta-analysis of randomized controlled trials.

Unlabelled: To investigate the impact of different types of exercise modalities on children and adolescents with developmental disorders. Data were obtained from randomized controlled trials retrieved from five databases. Following the PRISMA NMA guidelines, a Bayesian framework-based Markov chain Monte Carlo simulation was used for aggregation and analysis.

Highly stable silicon oxycarbide all-solid-state batteries enabled by machined learning accelerated screening of oxides and sulfides electrolytes.

Traditional trial-error approach severely limits and restricts rapid development of high-performance anode and electrolytes materials, searching huge parameters space of various anode-solid electrolyte interfaces in an effective and efficient way is the key issue. Here, a novel computational strategy combining machine learning and first-principles is proposed to achieve efficient high-throughput screening of oxides and sulfides electrolytes for highly stable silicon oxycarbide all-solid-state batteries. First-principles calculations demonstrate significant compact of material type and elemental doping on interfacial compatibility between silicon oxycarbide and various electrolytes.

Use of the Disposcope endoscope for awake orotracheal intubation in an elderly patient with a large vocal cord polyp -a case report.

Background: Vocal cord polyps are commonly encountered in the otorhinolaryngology department. The risk of anesthesia is high in patients with large vocal cord polyps. Awake intubation with appropriate airway tools provides a favorable safety profile.

Composition Design of Ni-Nano-Cu-BTC@Ag Coatings with Low Friction and Their Intelligent Electrical Control Behavior.

At present, Ni-based coatings are rarely used in the field of voltage control friction because of their poor antifriction, wear resistance, and conductive properties. Therefore, in this paper, Cu-BTC@Ag nanocrystals were used to enhance the nickel coatings, and the effect of voltage on their tribological properties was also investigated. It was found that the grains of coating were refined via the addition of Cu-BTC@Ag nanocrystals, leading to an improvement in the hardness and corrosion resistance of this composite coating.

Prevention of high-fat-diet-induced obesity in mice by soluble dietary fiber from fermented and unfermented millet bran.

Obesity-related diabetes, cardiovascular disease, and hypertension pose many risks to human health. Thus, mice on a high-fat diet were gavaged with millet bran (unfermented/fermented) soluble dietary fiber (RSDF/FSDF, 500 mg·kg) for 10 weeks in current research, and then evaluated the various biological indicators. These findings revealed that RSDF and FSDF supplements could prevent fat synthesis by inhibiting sterol regulatory element-binding protein-1c gene expression.

Detecting horizontal gene transfer with metagenomics co-barcoding sequencing.

Horizontal gene transfer (HGT) is the process through which genetic information is transferred between different genomes and that played a crucial role in bacterial evolution. HGT can enable bacteria to rapidly acquire antibiotic resistance and bacteria that have acquired resistance is spreading within the microbiome. Conventional methods of characterizing HGT patterns include short-read metagenomic sequencing (short-reads mNGS), long-read sequencing, and single-cell sequencing.

Non-targeted Metabolomics Analysis Reveals Distinct Metabolic Profiles Between Positive and Negative Emotional Tears of Humans: A Preliminary Study.

Background Basal, reflex, and emotional tears differ in chemical components. It is not yet known whether chemical differences exist in tears of different emotions. We investigated the biochemical basis of emotional tears by performing non-targeted metabolomics analyses of positive and negative emotional tears of humans.

Feasibility and safety of Post-Urgent PCI Same-DaY discharge (PUSDY Trial) in China: protocol for a multicentre randomised controlled trial.

Introduction: In the Chinese healthcare system, where there is overcrowding in hospitals, especially in tertiary care centres, adoption of same-day discharge (SDD) post-percutaneous coronary intervention (PCI) could potentially lead to significant savings of healthcare resources and costs. This study is a non-inferiority trial examining whether post-PCI SDD is feasible in China. The primary hypothesis is that patient outcomes in post-urgent PCI SDD patients are non-inferior to regular discharge patients.

Hemoglobin-to-Red Cell Distribution Width Ratio is Associated with All-Cause Mortality in Critically Ill Patients with Traumatic Brain Injury.

Background: Hemoglobin-to-red cell distribution width ratio (HRR) has shown good prognostic value in various cancers. However, the relationship between HRR and outcomes in critically ill patients with traumatic brain injury (TBI) remains unclear. This study aimed to investigate the association between HRR and mortality among critically ill patients with TBI.

Electronic-Control Friction Behavior of Porous Metal-Organic Framework@Ag Nanocrystals as Self-Repairing Lubricant Additive.

The low conductivity and poor antifriction performance of lubricants are the main causes of wear failure in mechanical equipment under electronic-control friction. Metal-organic framework (MOF) nanocomposites can be used to fabricate a new kind of lubricant additive. Herein, porous Cu-BTC@Ag MOF nanocrystals were successfully synthesized via an in situ generation method.

An Evidential Multi-Target Domain Adaptation Method Based on Weighted Fusion for Cross-Domain Pattern Classification.

For cross-domain pattern classification, the supervised information (i.e., labeled patterns) in the source domain is often employed to help classify the unlabeled target domain patterns.

Association between obesity and short- and medium-term mortality in critically ill patients with atrial fibrillation: a retrospective cohort study.

Background: There has been controversy about how obesity affects the clinical prognosis for patients with atrial fibrillation (AF), and the relationship between obesity and outcomes in critically ill patients with AF remains unclear. The purpose of this study was to explore the association between obesity and short- and medium-term mortality in critically ill patients with AF.

Methods: The Medical Information Mart for Intensive Care-IV (MIMIC-IV) database was used to conduct a retrospective cohort analysis on 9282 critically ill patients with AF.

Novel Mutations of PAX6 and WFS1 Associated With Congenital Cataract in a Chinese Family.

Background: Congenital cataract is a common cause of blindness in childhood. About half of the cases have a genetic etiology, and more than 100 genes have been associated with congenital cataracts. This study reports the clinical and genetic findings of a two-generation Chinese family affected by congenital cataract.

CiteSpace-based global science, technology, engineering, and mathematics education knowledge mapping analysis.

To better understand the latest developments in global science, technology, engineering, and mathematics (STEM) education research, this study collected STEM education research materials to sort out the development of STEM education as a whole, so as to get a clearer path and trend of STEM education development. This study conducted a visualization and quantitative analysis of the literature on STEM education research in Science Citation Index Extended (SCI-E) and Social Science Citation Index (SSCI) using the CiteSpace (5.8.

Relationship between red blood cell distribution width-to-albumin ratio and outcome of septic patients with atrial fibrillation: a retrospective cohort study.

Background: This retrospective cohort study aimed to investigate the association between red blood cell distribution width-to-albumin ratio (RAR) and in-hospital mortality in patients with sepsis and atrial fibrillation (AF).

Methods: Data were obtained from the Medical Information Mart for the Intensive Care Database IV database version 1.0.

Role of the Quorum-Sensing System in Enterococcus faecalis Bloodstream Infection.

Enterococcus faecalis is an important intestinal colonizing bacteria and can cause various tissue infections, including invasive blood infection (BI). The annual incidence of E. faecalis BI has been estimated to be ~4.

The Characteristic and Distribution of Shale Micro-Brittleness Based on Nanoindentation.

Shale is a special kind of rock mass and it is particularly important to evaluate its brittleness for the extraction of gas and oil from nanoporous shale. The current brittleness studies are mostly macro-evaluation methods, and there is a lack of a micro-brittleness index that is based on nanoindentation tests. In this paper, nanoindentation tests are carried out on the surface of shale to obtain mechanical property, and then a novel micro-brittleness index is proposed.

Tree-based, two-stage risk factor analysis for postoperative sepsis based on Sepsis-3 criteria in elderly patients: A retrospective cohort study.

Background: Sepsis remains the leading cause of postoperative death in elderly patients and is defined as organ dysfunction with proven or suspected infection according to Sepsis-3 criteria. To better avoid potential non-linear associations between the risk factors, we firstly used a tree-based analytic methods to explore the putative risk factors of geriatric sepsis based on the criteria in the study.

Methods: Data of 7,302 surgical patients aged ≥ 65 years at the Third Affiliated Hospital of Sun Yat-sen University from January 2015 to September 2020 were collected.

Rough Surface Characterization Parameter Set and Redundant Parameter Set for Surface Modeling and Performance Research.

Among the 26 roughness parameters described in ISO 25178 standard, the parameters used to characterize surface performance in characterization parameter set () lack scientificity and unity, resulting in application confusion. The current comes from empirical selection or small sample experiments, thus featuring low generality. A new method for constructing in rough surfaces is proposed to solve the above issues.

Solid-Liquid Interfacial Coordination Chemistry Enables High-Capacity Ammonium Storage in Amorphous Manganese Phosphate.

Ammonium (NH ) ion as charge carrier is attracting attention in aqueous batteries. Yet, most NH host materials are still limited by the relatively low capacities. Here, we fabricated a manganese phosphate (MP-20) for NH ion storage.