Peniapyrones A-I, Cytotoxic Tricyclic-Fused α-Pyrone Derivatives from an Endophytic F4a.

Five cyclopenta[]pyrano[4,3-]pyran-1,7(6)-dione 6/6/5-fused tricyclic ring system containing metabolites peniapyrones A-E (-), and four previously undescribed cyclopenta[4,5]furo[3,2-]pyran-1-one 6/5/5-fused tricyclic ring system containing compounds peniapyrones F-I (-), were isolated from the endophytic F4a. Their structures, including absolute configurations, were determined through spectroscopic analysis and quantum chemical calculations. Peniapyrones D () and E () were a pair of diastereoisomers.

Genome Mining and Molecular Networking Guided Isolation of Antimycin Analogs with Antifeedant Activities from the Deep-Sea-Derived Streptomyces sp. NA13.

Polyphagous insects could affect agricultural production, which leads to serious economic losses. Due to the negative effects of synthesized insecticides, finding eco-friendly and new biopesticides is emergent. To develop natural origin insecticides, an integrative approach combining antifeedant activity screening, genome mining, and molecular networking has been applied to discover antifeedant secondary metabolites from Streptomyces sp.