Wuling capsule combined with sertraline in the therapy of anxiety and depression with insomnia in adolescents.

Background: The treatment of adolescent patients with anxiety, depression and insomnia is challenging, and there is no ideal treatment method.

Aim: To evaluate the clinical efficacy of Wuling capsule combined with sertraline in the treatment of adolescent anxiety, depression and insomnia.

Methods: Eighty adolescent patients with anxiety, depression with insomnia who were admitted to our hospital from April 1, 2022 to March 30, 2024.

Association of altitude with all-cause and cardiovascular mortality among patients with hypertension: a cohort study in Southwest China.

Background: Available evidence falls short in assessing the risk of long-term outcomes among individuals with hypertension residing at various altitudes. We aimed to investigate the association between residential altitude and the risk of all-cause and cardiovascular disease (CVD) mortality among hypertensive patients.

Methods: This cohort study encompassed 67,275 hypertensive patients aged ≥35 years who participated in China's Basic Public Health Service Program in 2018.

Impact of graphene oxide disturbance on the structure and function of arbuscular mycorrhizal networks.

With the widespread application of graphene oxide (GO), its potential toxicity has received increasing attention. The extraradical mycelium of arbuscular mycorrhizal fungi (AMF) can extend from the roots of one plant to those of another, forming complex common mycorrhizal networks (CMNs) for the transfer of nutrients and infochemicals. However, the impact of GO on the structure and transfer function of CMNs remains unknown.

The comparison of the prevalence, awareness, treatment and control of hypertension among adults along the three provinces of the Lancang-Mekong River countries-China, Laos and Cambodia.

Background: Under the background of similar geography and culture in Lancang-Mekong countries and rapid changes in the regional economy and lifestyle, this study aimed to describe and compare the prevalence, awareness, treatment, and control of hypertension and assess the hypertension care cascade in three provinces of China, Laos, and Cambodia.

Methods: A cross-sectional study was conducted between 2021 and 2023 in the three provinces of Lancang-Mekong River countries using consistent investigative procedures. We included 11,005 participants aged ≥ 18 years from three provinces, and data were collected through questionnaires, physical examinations, and biochemical tests.

Mendelian randomization study of sodium-glucose cotransporter 2 inhibitors in cardiac and renal diseases.

Objective: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) target the reabsorption of sodium and glucose in the kidney proximal tubules to reduce blood sugar levels. However, clinical randomized controlled trials on SGLT2i have yielded inconsistent results, necessitating further research into their efficacy and safety for specific cardiac and renal diseases.

Methods: "Sodium in urine" was selected as a downstream biomarker of SGLT2i.

Artificial intelligence for small molecule anticancer drug discovery.

Introduction: The transition from conventional cytotoxic chemotherapy to targeted cancer therapy with small-molecule anticancer drugs has enhanced treatment outcomes. This approach, which now dominates cancer treatment, has its advantages. Despite the regulatory approval of several targeted molecules for clinical use, challenges such as low response rates and drug resistance still persist.

Krill oil: nutraceutical potential in skin health and disease.

Krill oil (KO), extracted from the Antarctic marine crustacean , is a nutrient-dense substance that includes rich profiles of -3 polyunsaturated fatty acids (-3 PUFAs), phospholipids (PLs), astaxanthin (ASX), as well as vitamins A and E, minerals, and flavonoids. As a high-quality lipid resource, KO has been widely used as a dietary supplement for its health-protective properties in recent years. KO has various benefits, including antioxidative, anti-inflammatory, metabolic regulatory, neuroprotective, and gut microbiome modulatory effects.

Waste rubber - Black pollution reframed as a global issue: Ecological challenges and sustainability initiatives.

In contrast to "white pollution" originating from waste plastics, waste rubber is often referred to as "black pollution." The quantity and variety of waste rubber are increasing at an alarming rate, with a considerable fraction entering the global ecosystem via various pathways. This study presents the first critical review of waste rubber research with a focus on the risks associated with toxicant discharge and existing problems in waste rubber disposal, management, and recycling practices.

Discovery of novel SOS1 inhibitors using machine learning.

Overactivation of the rat sarcoma virus (RAS) signaling is responsible for 30% of all human malignancies. Son of sevenless 1 (SOS1), a crucial node in the RAS signaling pathway, could modulate RAS activation, offering a promising therapeutic strategy for RAS-driven cancers. Applying machine learning (ML)-based virtual screening (VS) on small-molecule databases, we selected a random forest (RF) regressor for its robustness and performance.

A tryst of 'blood pressure control- sex- comorbidities': the odyssey of basic public health services in Yunnan in quest for truth.

Background: The Basic Public Health Service (BPHS), a recently announced free healthcare program, aims to combat the most prevalent Noncommunicable Disease-"Hypertension" (HTN)-and its risk factors on a nationwide scale. In China, there is a rife that HTN less impacts women during their lifetime. We, therefore, aimed to evaluate the sex disparity in hypertension patients with comorbidities among south-west Chinese and the contribution of BPHS to address that concern.

Delineation of riparian areas based on the application of two-dimension hydraulic modelling.

This paper presents a proposal for riparian area delineation relying on topographical, hydrological, vegetation, and soil data together with numerical modelling of the river hydrodynamics. The two-dimensional model Iber is used to simulate 2.5, 10, 50, and 100-years return period flood events, and new code is developed to simulate the main hydrological processes of the river-riparian system to generate riparian zone maps.

Optimizing the ecological network of resource-based cities to enhance the resilience of regional ecological networks.

Mineral extraction in resource-based cities has caused serious damage to the original ecology, resulting in poor regional vegetation growth, reduced carbon sequestration capacity, and reduced ecosystem resilience. Especially in resource-based cities with fragile ecology, the overall anti-interference ability of the environment is relatively worse. Seeking ecological network optimization solutions that can improve vegetation growth conditions on a large scale is an effective way to enhance the resilience of regional ecosystems.

Polydopamine based photothermal/photodynamic synchronous coating modified intraocular lens for efficient and safer posterior capsule opacification prevention.

Posterior capsule opacification (PCO), as one of the most common late complications after intraocular lens (IOL) implantation in cataract surgery, seriously affects patients' postoperative vision and surgical satisfaction, and can only be treated by laser incision of the posterior capsule. Although drug eluting coating modification have been proved to inhibit PCO effectively, the complicated coating methods and the potential toxicity of the antiproliferative drugs hinders its actual application. In this study, an indocyanine green (ICG) loaded polydopamine (PDA) coating modified IOL (IP-IOL) was designed to prevented PCO.

EPR Studies of Aβ42 Oligomers Indicate a Parallel In-Register β-Sheet Structure.

Aβ aggregation leads to the formation of both insoluble amyloid fibrils and soluble oligomers. Understanding the structures of Aβ oligomers is important for delineating the mechanism of Aβ aggregation and developing effective therapeutics. Here, we use site-directed spin labeling and electron paramagnetic resonance (EPR) spectroscopy to study Aβ42 oligomers prepared by using the protocol of Aβ-derived diffusible ligands.

All-optical free-space routing of upconverted light by metasurfaces via nonlinear interferometry.

All-optical modulation yields the promise of high-speed information processing. In this field, metasurfaces are rapidly gaining traction as ultrathin multifunctional platforms for light management. Among the featured functionalities, they enable light-wavefront manipulation and more recently demonstrated the ability to perform light-by-light manipulation through nonlinear optical processes.

Machine learning model to estimate probability of remission in patients with idiopathic membranous nephropathy.

Background: Idiopathic membranous nephropathy (IMN) is a type of nephrotic syndrome and the leading cause of chronic kidney disease. As far as we know, no predictive model for assessing the prognosis of IMN is currently available. This study aims to establish a nomogram to predict remission probability in patients with IMN and assists clinicians to make treatment decisions.

Assessing mammal population densities in response to urbanization using camera trap distance sampling.

Environmental filtering is deemed to play a predominant role in regulating the abundance and distribution of animals during the urbanization process. However, the current knowledge about the effects of urbanization on the population densities of terrestrial mammals is limited. In this study, we compared two invasive mammals (dogs and cats ) and three indigenous mammals (Siberian weasels , Amur hedgehogs , and Tolai hares ) in response to urbanization using camera trap distance sampling (CTDS) in the rural-urban landscape of Tianjin, China.

Developmental Mapping of Hair Follicles in the Embryonic Stages of Cashmere Goats Using Proteomic and Metabolomic Construction.

The hair follicle (HF) is the fundamental unit for fleece and cashmere production in cashmere goats and is crucial in determining cashmere yield and quality. The mechanisms regulating HF development in cashmere goats during the embryonic period remain unclear. Growing evidence suggests that HF development involves complex developmental stages and critical events, and identifying the underlying factors can improve our understanding of HF development.

Single-cell transcriptome analysis of the germ cells and somatic cells during mitotic quiescence stage in goats.

The mitotic quiescence of prospermatogonia is the event known to occur during genesis of the male germline and is tied to the development of the spermatogenic lineage. The regulatory mechanisms and the functional importance of this process have been demonstrated in mice; however, regulation of this process in human and domestic animal is still largely unknown. In this study, we employed single-cell RNA sequencing to identify transcriptional signatures of prospermatogonia and major somatic cell types in testes of goats at E85, E105, and E125.

Research on the coupling coordination and driving role of urbanization and ecological resilience in the middle and lower reaches of the Yangtze River.

Background: The growth of urbanization in the 20th and 21st centuries has resulted in unprecedented ecological security issues. The imbalance between urban development and internal ecological security is a growing concern.

Methods: Based on the urban development process and the characteristics of ecosystem resilience, the corresponding urbanization evaluation system ("scale-structure-benefit") and ecosystem resilience assessment model ("resistance-adaptability-restoring") were constructed to explore the changes in each dimension as well as to analyze the spatial and temporal changes and driving effects of the coupled coordination level of urbanization and ecological resilience using the coupled coordination degree (CCD) model and geographically and temporally weighted regression (GTWR).

Graphene oxide affects the symbiosis of legume-rhizobium and associated rhizosphere rhizobial communities.

The large-scale production and utilization of graphene oxide (GO) have raised concerns regarding its environmental exposure and potential risks. However, existing research on GO toxicity has primarily focused on individual organisms. Little attention has been given to the interaction between GO and the nitrogen-fixing symbiosis of legume-rhizobium.

Study on the Role of in the Regulation of Plasmid-Mediated -Induced Expression in .

Objective: In this study, we constructed knock-out and knock-in strains from a clinically isolated Kp1strain carrying in its plasmid and compared them with the Kp NTUH-K2044 strain to investigate the relationship between and -induced expression.

Methods: We created the gene deletion mutant strains Kp1-Δ and Kp NTUH-K2044-Δ with pKO3-km plasmid using homologous recombination technology. We constructed the Kp NTUH-K2044-RC and Kp NTUH-K2044-Δ-RC drug resistance model strains with plasmid pACYC184.