Stalking behaviour has long been recognized as causing great distress and prolonged psychological problems in many victims. Individuals subjected to stalking often feel powerless and helpless in the face of such unwelcome intrusions into their daily lives. There now seems to be a greater awareness and understanding of the phenomenon which, in turn, may encourage individuals affected to seek help.
View Article and Find Full Text PDFWe retrospectively analysed pregnancy complicated by diabetic nephropathy in patients attending a University teaching hospital (1990-97), to examine fetal/maternal outcomes. Fetal outcomes included early intrauterine deaths, stillbirths, neonatal/perinatal mortality, size for gestational age, malformations, and need for neonatal unit care. Maternal outcomes included change in frequency of hypertension or severe proteinuria, serum creatinine data, and caesarean section rate.
View Article and Find Full Text PDFObjective: To describe the characteristics of and outcome for impaired medical practitioners notified to the Medical Practitioners Board of Victoria.
Design: Retrospective review of records for all impaired practitioners notified to the Board for the first time from January 1983 to December 1997.
Outcome Measures: Number of notifications per year; characteristics of impaired practitioners; source of notification; diagnosis and diagnostic categories; actions by the Board; and outcomes for impaired practitioners.
Prospective studies of pre-conception diabetes care have confirmed its positive impact on the incidence of malformations by improving glycaemic control. Less information is available on the impact of pre-conception care on maternal and neonatal morbidity. This audit addresses its impact on timing and mode of delivery, incidence of macrosomia and rate of admission to neonatal unit care in addition to sociodemographic factors which may influence attendance at such a service.
View Article and Find Full Text PDFImpaired antioxidant defence is implicated in the development of cardiovascular complications in non-insulin-dependent diabetes (NIDDM). However, as many of these patients are elderly, observed changes in antioxidant status may be due to the patient's age rather than their disease. We sampled blood from 47 elderly NIDDM patients (21 male and 26 female; mean age +/- SD, 75.
View Article and Find Full Text PDFSerum cholesterol, triacylglycerols and low-density lipoprotein (LDL) subfractions were determined in 120 primagravid women during normal gestation (40 in each trimester) and in 20 non-pregnant age-matched controls. LDL subfractions were determined by PAGE, and an LDL score was calculated. The higher the score, the smaller the subfractions.
View Article and Find Full Text PDFInt J Clin Pract
November 1998
Recent statistics suggest hormone replacement therapy (HRT) is prescribed by only a small number of general practitioners (GPs), despite its use being widely discussed and advocated in the literature. In March 1997, we sent a questionnaire to 200 randomly selected practices in the south Birmingham area to try to find the reason. Eighty-one (40.
View Article and Find Full Text PDFInt J Clin Pract
March 1998
The benefits of hormone replacement therapy (HRT) in non-diabetic postmenopausal women are now well established. HRT improves climacteric symptoms and has beneficial effects on the cardiovascular system and the skeleton. In addition, recent studies suggest a reduced risk of Alzheimer's disease and colorectal cancer.
View Article and Find Full Text PDFThe aims of this study were to determine tumor necrosis factor-beta (TNF-beta) concentration profiles in peripheral venous plasma and amniotic fluid during pregnancy and at the time of labor and to characterise TNF-beta mRNA expression and TNF-beta release from human gestational tissues. In addition, we investigated the expression of TNF-beta binding protein, lymphotoxin-beta (LT-beta), in human gestational tissues. The mean (+/-S.
View Article and Find Full Text PDFClin Endocrinol (Oxf)
November 1995
Objective: Retrospective analysis suggests an increased mortality from cardiovascular disease in hypopituitary adults; GH deficiency has been postulated to account for this. However, glucocorticoid replacement doses of 30 mg/day of hydrocortisone (HC) may be excessive, and could therefore be implicated in the increased cardiovascular mortality in this group of patients. The aims of this study were to establish whether patients with hypopituitarism have any abnormalities of the cardiovascular system compared to a control group and whether any of these parameters might be improved by reducing the replacement dose of glucocorticoid.
View Article and Find Full Text PDFFibromyalgia syndrome (FMS) is characterised by generalised aches, pains, tender points, stiffness and fatigue, yet, despite increasing recognition of this syndrome as a clinical entity, its aetiology remains obscure. There is now increasing evidence that FMS represents a distinct rheumatic disorder and should not be regarded as a somatic illness secondary to psychiatric disorder.
View Article and Find Full Text PDFIn this study, the histological, cytological, and electron microscopical features of cervical atypical reserve cell hyperplasia are presented. The most important feature of atypical reserve cells in smears is the absence of cytoplasm. Thus, they must be recognized on the absence and not on the presence of a feature, which makes identifying these cells a controversial issue.
View Article and Find Full Text PDFAim: To assess parathyroid hormone related protein (PTHrP) as a candidate biochemical marker of invasion of the mandible by oral squamous cell carcinoma.
Methods: Tumour PTHrP concentrations were quantitated by immunoassay, and PTHrP was detected by immunohistochemistry, in a cohort of 24 primary squamous cell carcinomas of the mandible.
Results: PTHrP was identified in all tumours examined, but no correlation was found between scores of the intensity and/or consistency of staining or tumour PTHrP concentrations and the histological classification of tumour invasion.
Background: Parathyroid hormone-related protein (PTHrP) is the main tumor-derived factor responsible for the hypercalcemia of malignancy.
Methods: Using a polyclonal serum to the 37-67 region of PTHrP, and 35S-labeled riboprobes, the authors investigated the cellular expression of PTHrP mRNA and peptide in formalin fixed, paraffin embedded sections from 16 invasive cervical tumors. In addition, the relationship among the histologic cell type, degree of differentiation, pattern of invasion, and tumor expression of PTHrP were examined.
We describe a patient with a neuroendocrine tumour of the pancreas associated with hypercalcaemia which was attributed to production of parathyroid hormone-related protein (PTHrP) by the tumour. Plasma PTHrP 1-86 was significantly raised, and fell following surgical resection of the tumour. PTHrP mRNA and peptide were identified in tumour tissue by in-situ hybridization and immunohistochemistry respectively.
View Article and Find Full Text PDFParathyroid hormone related protein (PTHrP) is an important humoral factor in hypercalcaemia of malignancy. In addition there is increasing evidence that this peptide has a physiological role in fetal development, especially in cellular growth and differentiation. Both in-situ hybridization and immunohistochemistry were used together and for the first time to identify sites of PTHrP gene expression and peptide in fetal and extra-embryonic tissues of first trimester human pregnancy.
View Article and Find Full Text PDFMany young people experiment with alcohol and drugs and a small minority meet the criteria for substance dependency. Yet substance misuse may be overlooked in children presenting with behavioural problems, difficulties at school and associated poor academic performance. This article considers the implications for management and prevention.
View Article and Find Full Text PDFParathyroid hormone-related protein (PTHrP) is an important humoral factor in the syndrome of humoral hypercalcaemia of malignancy (HHM) and its importance is evident by the many studies examining either PTHrP mRNA expression, intracellular peptide, or circulating PTHrP levels in patients with malignancy. However, the relationship between PTHrP mRNA expression, intracellular localization of peptide, and circulating PTHrP levels in the same group of patients with malignancy has not been examined. This study was carried out to explore this relationship in a group of patients with solid tumours associated with either normocalcaemia or hypercalcaemia.
View Article and Find Full Text PDFObjective: Previous literature reports have suggested that osteoporosis associated with pregnancy is a rare event. We have examined the prevalence of this condition and compiled data on the largest group of such patients in the literature.
Patients And Design: With the help of the National Osteoporosis Society 35 women with pregnancy associated osteoporosis were identified.
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